MolNFT v1 · #478172 · protein
AlphaFold monomer V2.0 prediction for transient receptor potential cation channel subfamily M member 8 (Q8R4D5)
Q8R4D5: “AlphaFold monomer V2.0 prediction for transient receptor potential cation channel subfamily M member 8…”. 13 pockets (best druggability 0.76). MolNFT v1 #478172 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q8R4D5
- Type
- protein
- Length
- 1,104 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xcd38ee57516af74F8e67f1085a39c3741e4C0cda
- Molecule
- Transient receptor potential cation channel subfamily M member 8
- UniProt
- Q8R4D5
- Pockets
- 13 · best druggability 0.76
Structure
1 distinct chain · 60% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transient receptor potential cation channel subfamily M member 8 | protein | 1104 | 60% helix, 8% strand | Q8R4D5 |
Pockets
13 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 679 | 0.76 | 0.81 | 65 | empty |
| 2 | 364 | 0.68 | 0.81 | 51 | empty |
| 3 | 177 | 0.56 | 0.80 | 26 | empty |
| 4 | 261 | 0.54 | 0.76 | 43 | empty |
| 5 | 193 | 0.50 | 0.76 | 25 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7WRC · Mouse TRPM8 in lmng in the presence of calcium, icilin and PI(4,5)P2 · an experimental structure of the same protein · chain A against A, TM-score 0.76
- 7WRE · Mouse TRPM8 in lipid nanodiscs in the presence of calcium and icilin · an experimental structure of the same protein · chain A against A, TM-score 0.76
- 7WRF · Mouse TRPM8 in lipid nanodiscs in the presence of calcium, icilin and PI(4,5)P2 · an experimental structure of the same protein · chain A against A, TM-score 0.76
- 7WRB · Mouse TRPM8 in LMNG in the presence of calcium · an experimental structure of the same protein · chain A against A, TM-score 0.76
- 7WRB · Mouse TRPM8 in lmng in the presence of calcium · an experimental structure of the same protein · chain A against A, TM-score 0.76
- 7WRD · Mouse TRPM8 in lmng in the presence of calcium and icilin · an experimental structure of the same protein · chain A against A, TM-score 0.76
- 7WRA · Mouse TRPM8 in lmng in ligand-free state · an experimental structure of the same protein · chain A against A, TM-score 0.76
- 9B6F · Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist AMG2850 · an experimental structure of the same protein · chain A against A, TM-score 0.75
- 9B6H · Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist TC-I 2014 and… · an experimental structure of the same protein · chain A against B, TM-score 0.75
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8R4D5
- Elsewhere: UniProt Q8R4D5 · AlphaFold DB Q8R4D5
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