Research workbench
Trh-trhr G protein complex
Analyse Trh-trhr G protein complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7WKD
- Type
- protein
- Length
- 1,120 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gq; Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; SCFV16; Guanine…
- UniProt
- P62873, P59768, P34981
- Pockets
- 15 · best druggability 0.81
Structure
electron microscopy · 6 distinct chains · 34% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Gq | protein | 232 | 46% helix, 15% strand | — |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 338 | 7% helix, 48% strand | P62873 |
| E | SCFV16 | protein | 230 | 3% helix, 47% strand | — |
| G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 54 | 57% helix, 0% strand | P59768 |
| R | Thyrotropin-releasing hormone receptor | protein | 263 | 82% helix, 2% strand | P34981 |
| C | Trh | protein | 3 | 0% helix, 0% strand | — |
Pockets
15 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 596 | 0.81 | 0.86 | 58 | empty |
| 2 | 1127 | 0.80 | 0.81 | 83 | empty |
| 3 | 110 | 0.55 | 0.84 | 33 | empty |
| 4 | 257 | 0.52 | 0.75 | 43 | empty |
| 5 | 159 | 0.49 | 0.78 | 24 | empty |
Interfaces
7 interfaces between chains.
- B–G · 2040 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 1471 Ų buried · 15 hydrogen bonds · protein-protein
- A–R · 1149 Ų buried · 6 hydrogen bonds · protein-protein
- A–E · 608 Ų buried · 11 hydrogen bonds · protein-protein
- B–E · 440 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (cyclization, nonstandard).
Compared structures
- 7WKD · TRH-TRHR G protein complex · the same entry in another collection · chain C against C, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.95
- P34981 · AlphaFold monomer V2.0 prediction for thyrotropin-releasing hormone receptor (P34981) · a predicted model of the same protein · chain R against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Every structure of UniProt P34981
- Elsewhere: RCSB PDB 7WKD · PDBe 7WKD · UniProt P62873 · UniProt P59768 · UniProt P34981
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.