UniProt P34981
Thyrotropin-releasing hormone receptor (P34981)
Thyrotropin-releasing hormone receptor (UniProt P34981): 7 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 22 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P34981
- Protein
- Thyrotropin-releasing hormone receptor
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 22 · 5 records with a druggable one
Structures
8 records of P34981 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7WKD | TRH-TRHR G protein complex | electron microscopy | R | — | 5 (best 0.80) |
| 7WKD | Trh-trhr G protein complex | electron microscopy | R | — | — |
| 7X1T | Structure of Thyrotropin-Releasing Hormone Receptor bound with Taltirelin. | electron microscopy | A | — | 6 (best 0.75) |
| 7X1T | Structure of thyrotropin-releasing hormone receptor bound with taltirelin. | electron microscopy | A | RGI, NH2 | — |
| 7X1U | Structure of Thyrotropin-Releasing Hormone Receptor bound with an Endogenous Peptide Agonist TRH. | electron microscopy | A | — | 4 (best 0.73) |
| 7X1U | Structure of thyrotropin-releasing hormone receptor bound with an endogenous peptide agonist trh. | electron microscopy | A | NH2 | — |
| 7XW9 | Cryo-EM structure of the TRH-bound human TRHR-Gq complex | electron microscopy | R | — | 4 (best 0.78) |
| P34981 | AlphaFold monomer V2.0 prediction for thyrotropin-releasing hormone receptor (P34981) | predicted | A | — | 3 (best 0.76) |
Ligands
Experiment against prediction
- 7WKD chain R against the predicted model P34981: TM-score 0.93, RMSD 1.86 Å
- 7WKD chain R against the predicted model P34981: TM-score 0.93, RMSD 1.86 Å
- 7XW9 chain R against the predicted model P34981: TM-score 0.93, RMSD 2.07 Å
- 7X1T chain A against the predicted model P34981: TM-score 0.93, RMSD 2.01 Å
- 7X1T chain A against the predicted model P34981: TM-score 0.93, RMSD 2.01 Å
- 7X1U chain A against the predicted model P34981: TM-score 0.92, RMSD 2.01 Å
- 7X1U chain A against the predicted model P34981: TM-score 0.92, RMSD 2.01 Å
Elsewhere
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