MolNFT v1 · #190412 · protein
Structure of thyrotropin-releasing hormone receptor bound with an endogenous peptide agonist trh.
7X1U · Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit…: “Structure of thyrotropin-releasing hormone receptor bound with an endogenous peptide agonist trh.”. Electron microscopy, 1 ligand (NH2), 14 pockets (best druggability…
- PDB
- 7X1U
- Type
- protein
- Length
- 1,082 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2; Thyrotropin-releasing…
- UniProt
- P63212, P34981, P62871
- Ligands
- NH2
- Pockets
- 14 · best druggability 0.81
Structure
electron microscopy · 6 distinct chains · 23% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| F | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 49 | 29% helix, 0% strand | P63212 |
| A | Thyrotropin-releasing hormone receptor | protein | 271 | 59% helix, 4% strand | P34981 |
| B | Mini-G alpha Q prtoein | protein | 221 | 28% helix, 15% strand | — |
| C | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 330 | 3% helix, 35% strand | P62871 |
| D | SCFV16 | protein | 208 | 1% helix, 18% strand | — |
| E | Endogenous peptide agonist trh | protein | 3 | 0% helix, 0% strand | — |
Ligands and binding sites
- NH2 · Amino group · ion · chains A, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 557 | 0.81 | 0.86 | 52 | empty |
| 2 | 1083 | 0.73 | 0.76 | 75 | empty |
| 3 | 311 | 0.72 | 0.85 | 55 | empty |
| 4 | 71 | 0.72 | 0.96 | 18 | empty |
| 5 | 162 | 0.67 | 0.87 | 31 | empty |
Interfaces
8 interfaces between chains.
- F–C · 1321 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 1320 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 1058 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 537 Ų buried · 2 hydrogen bonds · protein-protein
- A–E · 396 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide, 1 modified (disulfide, cyclization).
Compared structures
- 7X1U · Structure of Thyrotropin-Releasing Hormone Receptor bound with an Endogenous Peptide… · the same entry in another collection · chain E against E, TM-score 1.00
- P62871 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain C against A, TM-score 0.98
- P34981 · AlphaFold monomer V2.0 prediction for thyrotropin-releasing hormone receptor (P34981) · a predicted model of the same protein · chain A against A, TM-score 0.92
- P63212 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain F against A, TM-score 0.60
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63212
- Every structure of UniProt P34981
- Every structure of UniProt P62871
- Elsewhere: RCSB PDB 7X1U · PDBe 7X1U · UniProt P63212 · UniProt P34981 · UniProt P62871
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