Research workbench
Telomeric tetranucleosome
Analyse Telomeric tetranucleosome in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7V9K
- Type
- protein + DNA
- Length
- 4,251 residues
- Chains
- 34
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone H3.1; Histone H4; Histone H2A type 1-B/E; Histone H2B type 1-K; DNA (539-mer)
- UniProt
- P68431, P62805, P04908, O60814
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 12 distinct chains · 58% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E, K, O, S, W, a, e | Histone H3.1 | protein | 100 | 62% helix, 1% strand | P68431 |
| B, P, b | Histone H4 | protein | 84 | 61% helix, 4% strand | P62805 |
| C, U, c | Histone H2A type 1-B/E | protein | 109 | 54% helix, 4% strand | P04908 |
| D, N, V, d | Histone H2B type 1-K | protein | 99 | 70% helix, 2% strand | O60814 |
| F, L, f | Histone H4 | protein | 87 | 59% helix, 5% strand | P62805 |
| G, g | Histone H2A type 1-B/E | protein | 120 | 49% helix, 3% strand | P04908 |
| H, R, Z, h | Histone H2B type 1-K | protein | 98 | 70% helix, 1% strand | O60814 |
| M | Histone H2A type 1-B/E | protein | 119 | 50% helix, 3% strand | P04908 |
| Q, Y | Histone H2A type 1-B/E | protein | 110 | 52% helix, 5% strand | P04908 |
| T, X | Histone H4 | protein | 83 | 61% helix, 4% strand | P62805 |
| I | DNA (539-mer) | dna | 539 | — | — |
| J | DNA (539-mer) | dna | 539 | — | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 988 | 0.80 | 0.82 | 76 | empty |
| 2 | 674 | 0.80 | 0.84 | 62 | empty |
| 3 | 1200 | 0.79 | 0.81 | 105 | empty |
| 4 | 903 | 0.79 | 0.82 | 72 | empty |
| 5 | 611 | 0.78 | 0.84 | 60 | empty |
Interfaces
156 interfaces between chains.
- I–J · 24407 Ų buried · 1,324 hydrogen bonds · nucleic-nucleic
- O–P · 2680 Ų buried · 19 hydrogen bonds · protein-protein
- K–L · 2596 Ų buried · 16 hydrogen bonds · protein-protein
- S–T · 2577 Ų buried · 14 hydrogen bonds · protein-protein
- a–b · 2573 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 7V9K · Telomeric tetranucleosome · the same entry in another collection · chain G against G, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P68431
- Every structure of UniProt P62805
- Every structure of UniProt P04908
- Every structure of UniProt O60814
- Elsewhere: RCSB PDB 7V9K · PDBe 7V9K · UniProt P68431 · UniProt P62805 · UniProt P04908 · UniProt O60814
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