Research workbench
NMR structure of the cntnc-ctni chimera bound to W8
Analyse NMR structure of the cntnc-ctni chimera bound to W8 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7UH9
- Type
- protein
- Length
- 125 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Troponin C, slow skeletal and cardiac MUSCLES,TROPONIN I, cardiac muscle
- UniProt
- P63316, P19429
- Ligands
- WW9, CA
- Pockets
- 1 · best druggability 0.66
Structure
solution nmr · 1 distinct chain · 54% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Troponin C, slow skeletal and cardiac MUSCLES,TROPONIN I, cardiac muscle | protein | 125 | 54% helix, 2% strand | P63316, P19429 |
Ligands and binding sites
- WW9 · N-(7-aminoheptyl)-5-chloronaphthalene-1-sulfonamide · ligand · chains A
- CA · Calcium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 275 | 0.66 | 0.82 | 31 | WW9 |
Compared structures
- 7UH9 · NMR structure of the cNTnC-cTnI chimera bound to W8 · the same entry in another collection · chain A against A, TM-score 1.00
- P63316 · AlphaFold monomer V2.0 prediction for troponin C, slow skeletal and cardiac muscles… · a predicted model of the same protein · chain A against A, TM-score 0.65
- P19429 · AlphaFold monomer V2.0 prediction for troponin I, cardiac muscle (P19429) · a predicted model of the same protein · chain A against A, TM-score 0.23
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63316
- Every structure of UniProt P19429
- Elsewhere: RCSB PDB 7UH9 · PDBe 7UH9 · UniProt P63316 · UniProt P19429
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