Crystal structure of arabidopsis thaliana acetohydroxyacid synthase W574L mutant in complex with bispyribac-sodium

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 17% strand (DSSP).

Ligands and binding sites

• 6QL · 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid · ligand · chains A
• FAD · Flavin-adenine dinucleotide · ligand · chains A
• TZD · 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogen diphosphate · ligand · chains A
• MG · Magnesium ion · metal · chains A
• SO4 · Sulfate ion · ion · chains A
• NHE · 2-[N-cyclohexylamino]ethane sulfonic acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 7U25 · Crystal structure of arabidopsis thaliana acetohydroxyacid synthase W574L mutant in… · the same entry in another collection · chain A against A, TM-score 1.00
• P17597 · AlphaFold monomer V2.0 prediction for acetolactate synthase, chloroplastic (P17597) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P17597
• Elsewhere: RCSB PDB 7U25 · PDBe 7U25 · UniProt P17597