UniProt P17597
Acetolactate synthase, chloroplastic (P17597)
Acetolactate synthase, chloroplastic (UniProt P17597), EC 2.2.1.6: 37 experimental structures and 1 predicted model on GenesisL1, 21 ligands bound, 16 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P17597
- Protein
- Acetolactate synthase, chloroplastic
- EC
- 2.2.1.6
- Experimental structures
- 37
- Predicted models
- 1
- Ligands
- 21
- Pockets
- 16 · 3 records with a druggable one
Structures
38 records of P17597 in the MolNFT archive: 37 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1YBH | Crystal structure of Arabidopsis thaliana Acetohydroxyacid synthase In Complex With A Sulfonylurea… | x-ray diffraction | A | — | — |
| 1YBH | Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea… | x-ray diffraction | A | — | — |
| 1YHY | Crystal structure of Arabidopsis thaliana Acetohydroxyacid synthase In Complex With A Sulfonylurea… | x-ray diffraction | A | — | — |
| 1YHY | Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea… | x-ray diffraction | A | — | — |
| 1YHZ | Crystal structure of Arabidopsis thaliana Acetohydroxyacid synthase In Complex With A Sulfonylurea… | x-ray diffraction | A | — | — |
| 1YHZ | Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea… | x-ray diffraction | A | — | — |
| 1YI0 | Crystal structure of Arabidopsis thaliana Acetohydroxyacid synthase In Complex With A Sulfonylurea… | x-ray diffraction | A | — | — |
| 1YI0 | Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea… | x-ray diffraction | A | — | — |
| 1YI1 | Crystal structure of Arabidopsis thaliana Acetohydroxyacid synthase In Complex With A Sulfonylurea… | x-ray diffraction | A | — | — |
| 1YI1 | Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea… | x-ray diffraction | A | — | — |
| 1Z8N | Crystal structure of Arabidopsis thaliana Acetohydroxyacid synthase In Complex With An Imidazoli… | x-ray diffraction | A | — | — |
| 1Z8N | Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an… | x-ray diffraction | A | — | — |
| 3E9Y | Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron | x-ray diffraction | A | — | — |
| 3E9Y | Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron | x-ray diffraction | A | — | — |
| 3EA4 | Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester | x-ray diffraction | A | — | — |
| 3EA4 | Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester | x-ray diffraction | A | — | — |
| 5K2O | Crystal structure of Arabidopsis thaliana acetohydroxyacid synthase in complex with a… | x-ray diffraction | A | MG, FAD, 6QK, TP9 | 6 (best 0.79) |
| 5K2O | Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a… | x-ray diffraction | A | MG, FAD, 6QK, TP9 | — |
| 5K3S | Crystal structure of Arabidopsis thaliana acetohydroxyacid synthase in complex with a… | x-ray diffraction | A | MG, FAD, 6QL, TP9 | — |
| 5K3S | Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a… | x-ray diffraction | A | MG, FAD, 6QL, TP9 | — |
| 5K6Q | Crystal structure of arabidopsis thaliana acetohydroxyacid synthase catalytic subunit | x-ray diffraction | A | MG, FAD, TDM | — |
| 5K6R | Crystal structure of Arabidopsis thaliana acetohydroxyacid synthase in complex with a… | x-ray diffraction | A | MG, FAD, 6R5, K, TZD | — |
| 5K6R | Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a… | x-ray diffraction | A | MG, FAD, 6R5, K, TZD | — |
| 5K6T | Crystal structure of Arabidopsis thaliana acetohydroxyacid synthase in complex with a… | x-ray diffraction | A | MG, FAD, 6R4, K, TZD | — |
| 5K6T | Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a… | x-ray diffraction | A | MG, FAD, 6R4, K, TZD | — |
| 5WJ1 | Crystal structure of Arabidopsis thaliana acetohydroxyacid synthase in complex with a… | x-ray diffraction | A | MG, FAD, K, PXD, F50, TP9 | — |
| 5WJ1 | Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a… | x-ray diffraction | A | MG, FAD, K, PXD, F50, TP9 | — |
| 6U9H | Arabidopsis thaliana acetohydroxyacid synthase complex | electron microscopy | A, B, H, I, L, M, P, Q | MG, FAD, TPP | — |
| 6VZ8 | Arabidopsis thaliana acetohydroxyacid synthase complex with valine bound | electron microscopy | D, E, H, I, L, M, P, Q | MG, FAD, TPP | — |
| 6VZ8 | Arabidopsis thaliana acetohydroxyacid synthase complex with valine bound | electron microscopy | D, E, H, I, L, M, P, Q | MG, FAD, TPP | — |
| 7STQ | Crystal structure of arabidopsis thaliana acetohydroxyacid synthase W574L mutant in complex with… | x-ray diffraction | A | MG, FAD, CIE, TZD, SO4 | — |
| 7TZZ | Crystal structure of arabidopsis thaliana acetohydroxyacid synthase P197T mutant in complex with… | x-ray diffraction | A | MG, FAD, 6QL, AUJ, PO4, SO4 | — |
| 7U1D | Crystal structure of arabidopsis thaliana acetohydroxyacid synthase P197T mutant in complex with… | x-ray diffraction | A | MG, FAD, CIE, F50, TP9, SO4 | — |
| 7U1U | Crystal structure of arabidopsis thaliana acetohydroxyacid synthase W574L mutant | x-ray diffraction | A | MG, FAD, TPP, SO4 | — |
| 7U25 | Crystal structure of arabidopsis thaliana acetohydroxyacid synthase W574L mutant in complex with… | x-ray diffraction | A | MG, 6QL, FAD, TZD, SO4 | — |
| 9C4P | Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with… | x-ray diffraction | A | MG, FAD, A1AUE, SRT, AUJ, SO4 | 5 (best 0.80) |
| 9C4Q | Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with newly… | x-ray diffraction | A | MG, FAD, AUJ, OXY, A1AUH, SO4 | 5 (best 0.79) |
| P17597 | AlphaFold monomer V2.0 prediction for acetolactate synthase, chloroplastic (P17597) | predicted | A | — | — |
Ligands
- FAD · Flavin-adenine dinucleotide · in 21 records
- MG · Magnesium ion · in 21 records
- SO4 · Sulfate ion · in 7 records
- TP9 · (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate · in 7 records
- K · Potassium ion · in 6 records
- TZD · 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogen diphosphate · in 6 records
- 6QL · 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid · in 4 records
- TPP · Thiamine diphosphate · in 4 records
- AUJ · 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1, 3-thiazol-5-yl]ethyl phosphono hydrogen phosphate · in 3 records
- F50 · Ethaneperoxoic acid · in 3 records
- 6QK · 2-chloranyl-6-(4,6-dimethoxypyrimidin-2-yl)sulfanyl-benzoic acid · in 2 records
- 6R4 · methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate · in 2 records
- 6R5 · methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate · in 2 records
- CIE · 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl) amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester · in 2 records
- PXD · 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2, 4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl) benzenesulfonamide · in 2 records
- A1AUE · 2-(2-chloroethoxy)-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]benzene-1-sulfonamide · in 1 record
- A1AUH · 2-(2-fluoroethoxy)-N-[(4-methoxy-6-methylpyrimidin-2-yl)carbamoyl]benzene-1-sulfonamide · in 1 record
- OXY · Oxygen molecule · in 1 record
- PO4 · Phosphate ion · in 1 record
- SRT · S,R meso-tartaric acid · in 1 record
- TDM · 2-[(2E)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyl trihydrogen diphosphate · in 1 record
Experiment against prediction
- 1YBH chain A against the predicted model P17597: TM-score 1.00, RMSD 0.18 Å
- 1YBH chain A against the predicted model P17597: TM-score 1.00, RMSD 0.18 Å
- 9C4P chain A against the predicted model P17597: TM-score 1.00, RMSD 0.19 Å
- 5WJ1 chain A against the predicted model P17597: TM-score 1.00, RMSD 0.20 Å
- 5WJ1 chain A against the predicted model P17597: TM-score 1.00, RMSD 0.20 Å
- 3EA4 chain A against the predicted model P17597: TM-score 1.00, RMSD 0.20 Å
- 3EA4 chain A against the predicted model P17597: TM-score 1.00, RMSD 0.20 Å
- 9C4Q chain A against the predicted model P17597: TM-score 1.00, RMSD 0.20 Å
- 1YI0 chain A against the predicted model P17597: TM-score 1.00, RMSD 0.20 Å
- 1YI0 chain A against the predicted model P17597: TM-score 1.00, RMSD 0.20 Å
Elsewhere
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