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Ligand · 1CS

1CS · 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-L,3,5-triazin-2-yl)urea

1CS, 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-L,3,5-triazin-2-yl)urea (C12 H12 Cl N5 O4 S, 357.8 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å…

Component
1CS
Formula
C12 H12 Cl N5 O4 S
Class
ligand
Structures
4
PDB entries
2

Binding sites

1CS in 4 structures; the first of them:

  • 1T9B · Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea… · 1CS A695 · binds MET354, ASP379, ARG380, MET582, VAL583, TRP586, GLY116, ALA117 and 7 more
  • 1YHZ · Crystal structure of Arabidopsis thaliana Acetohydroxyacid synthase In Complex With A… · 1CS A695 · binds MET351, ASP376, ARG377, MET570, VAL571, TRP574, SER653
  • 1T9B · Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea… · 1CS A695 · binds MET354, ASP379, ARG380, MET582, VAL583, TRP586, GLY116, ALA117 and 7 more
  • 1YHZ · Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a… · 1CS A695 · binds MET351, ASP376, ARG377, MET570, VAL571, TRP574, SER653

Residues it binds most

ALA 4, MET 6, VAL 6, ARG 6, ASP 6, TRP 6, GLY 4, LEU 4, LYS 4, PHE 4 (residue and the binding sites it lines).

Found with

  • FAD · Flavin-adenine dinucleotide
  • P22 · Ethyl dihydrogen diphosphate
  • MG · Magnesium ion
  • NSP · 5-(aminomethyl)-2-methylpyrimidin-4-amine
  • P25 · Pentyl trihydrogen diphosphate
  • YF3 · 2-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}propane-1-thiol
  • K · Potassium ion
  • NHE · 2-[N-cyclohexylamino]ethane sulfonic acid

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