Research workbench
Human telomerase H/ACA rnp at 3.3 ångström
Analyse Human telomerase H/ACA rnp at 3.3 ångström in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7TRC
- Type
- protein + RNA
- Length
- 1,691 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Telomerase cajal body protein 1; H/ACA ribonucleoprotein complex subunit DKC1; H/ACA…
- EC
- 5.4.99.-
- UniProt
- Q9BUR4, O60832, Q9NPE3, Q9NY12, Q9NX24
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 8 distinct chains · 20% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| K | Telomerase cajal body protein 1 | protein | 330 | 2% helix, 41% strand | Q9BUR4 |
| G | H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) | protein | 341 | 26% helix, 28% strand | O60832 |
| J, F | H/ACA ribonucleoprotein complex subunit 3 | protein | 64 | 20% helix, 19% strand | Q9NPE3 |
| B | Telomerase RNA, partial sequence | rna | 92 | — | — |
| H | H/ACA ribonucleoprotein complex subunit 1 | protein | 94 | 3% helix, 43% strand | Q9NY12 |
| I, E | H/ACA ribonucleoprotein complex subunit 2 | protein | 129 | 43% helix, 13% strand | Q9NX24 |
| D | H/ACA ribonucleoprotein complex subunit 1 | protein | 91 | 10% helix, 47% strand | Q9NY12 |
| C | H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) | protein | 357 | 28% helix, 28% strand | O60832 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 755 | 0.81 | 0.85 | 62 | empty |
| 2 | 528 | 0.77 | 0.84 | 55 | empty |
| 3 | 1100 | 0.76 | 0.78 | 78 | empty |
| 4 | 755 | 0.76 | 0.80 | 44 | empty |
| 5 | 543 | 0.72 | 0.81 | 54 | empty |
Interfaces
21 interfaces between chains.
- G–B · 2216 Ų buried · 30 hydrogen bonds · protein-nucleic
- F–C · 1852 Ų buried · 17 hydrogen bonds · protein-protein
- G–J · 1845 Ų buried · 13 hydrogen bonds · protein-protein
- G–C · 1491 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 1318 Ų buried · 19 hydrogen bonds · protein-nucleic
Compared structures
- 7TRC · Human telomerase H/ACA RNP at 3.3 Angstrom · the same entry in another collection · chain C against C, TM-score 1.00
- Q9BUR4 · AlphaFold monomer V2.0 prediction for telomerase cajal body protein 1 (Q9BUR4) · a predicted model of the same protein · chain K against A, TM-score 0.98
- O60832 · AlphaFold monomer V2.0 prediction for H/ACA ribonucleoprotein complex subunit DKC1… · a predicted model of the same protein · chain G against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BUR4
- Every structure of UniProt O60832
- Every structure of UniProt Q9NPE3
- Every structure of UniProt Q9NY12
- Every structure of UniProt Q9NX24
- Elsewhere: RCSB PDB 7TRC · PDBe 7TRC · UniProt Q9BUR4 · UniProt O60832 · UniProt Q9NPE3 · UniProt Q9NY12 · UniProt Q9NX24
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