UniProt O60832
H/ACA ribonucleoprotein complex subunit DKC1 (O60832)
H/ACA ribonucleoprotein complex subunit DKC1 (UniProt O60832), EC 5.4.99.-: 7 experimental structures and 1 predicted model on GenesisL1, 63 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- O60832
- Protein
- H/ACA ribonucleoprotein complex subunit DKC1
- EC
- 5.4.99.-
- Experimental structures
- 7
- Predicted models
- 1
- Pockets
- 63 · 4 records with a druggable one
Structures
8 records of O60832 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7BGB | The H/ACA rnp lobe of human telomerase | electron microscopy | G, C | — | — |
| 7TRC | Human telomerase H/ACA RNP at 3.3 Angstrom | electron microscopy | G, C | — | 14 (best 0.81) |
| 7TRC | Human telomerase H/ACA rnp at 3.3 ångström | electron microscopy | G, C | — | — |
| 7V9A | biogenesis module of human telomerase holoenzyme | electron microscopy | C, G | — | 14 (best 0.82) |
| 7V9A | Biogenesis module of human telomerase holoenzyme | electron microscopy | C, G | — | — |
| 8OUE | The H/ACA RNP lobe of human telomerase with the dyskerin thumb loop in a semi-closed conformation | electron microscopy | C, G | — | 17 (best 0.81) |
| 8OUF | The H/ACA RNP lobe of human telomerase with the dyskerin thumb loop in an open conformation | electron microscopy | C, G | — | 18 (best 0.84) |
| O60832 | AlphaFold monomer V2.0 prediction for H/ACA ribonucleoprotein complex subunit DKC1 (O60832) | predicted | A | — | — |
Experiment against prediction
- 7TRC chain G against the predicted model O60832: TM-score 0.97, RMSD 1.32 Å
- 7TRC chain G against the predicted model O60832: TM-score 0.97, RMSD 1.32 Å
- 8OUE chain G against the predicted model O60832: TM-score 0.96, RMSD 1.72 Å
- 8OUF chain G against the predicted model O60832: TM-score 0.96, RMSD 1.64 Å
- 7TRC chain C against the predicted model O60832: TM-score 0.95, RMSD 1.81 Å
- 7TRC chain C against the predicted model O60832: TM-score 0.95, RMSD 1.81 Å
- 7BGB chain G against the predicted model O60832: TM-score 0.94, RMSD 1.68 Å
- 7BGB chain C against the predicted model O60832: TM-score 0.94, RMSD 1.88 Å
- 7V9A chain G against the predicted model O60832: TM-score 0.93, RMSD 1.98 Å
- 7V9A chain G against the predicted model O60832: TM-score 0.93, RMSD 1.98 Å
Elsewhere
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