Research workbench
Cryo-EM structure of the human nax channel in complex with BETA3 solved in gdn
Analyse Cryo-EM structure of the human nax channel in complex with BETA3 solved in gdn in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7TJ9
- Type
- protein
- Length
- 1,273 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q01118, Q9NY72
- Ligands
- PLM, PEV, POV, CLR, Q7G, NAG
Structure
electron microscopy · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 1111 | — | Q01118 |
| B | — | protein | 162 | — | Q9NY72 |
Ligands and binding sites
- PLM · Palmitic acid · ligand · 8 copies · chains A
- PEV · (1S)-2-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate · ligand · 3 copies · chains A
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · ligand · 3 copies · chains A
- CLR · Cholesterol · ligand · 2 copies · chains A
- Q7G · 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta, 17beta,25r)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside · ligand · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 7 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7TJ9 · Cryo-EM structure of the human Nax channel in complex with beta3 solved in GDN · the same entry in another collection · chain A against A, TM-score 1.00
- Q01118 · AlphaFold monomer V2.0 prediction for sodium channel protein type 7 subunit alpha (Q01118) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q9NY72 · AlphaFold monomer V2.0 prediction for sodium channel subunit beta-3 (Q9NY72) · a predicted model of the same protein · chain B against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q01118
- Every structure of UniProt Q9NY72
- Elsewhere: RCSB PDB 7TJ9 · PDBe 7TJ9 · UniProt Q01118 · UniProt Q9NY72
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