UniProt Q01118
Sodium channel protein type 7 subunit alpha (Q01118)
Sodium channel protein type 7 subunit alpha (UniProt Q01118): 4 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 60 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q01118
- Protein
- Sodium channel protein type 7 subunit alpha
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 60 · 3 records with a druggable one
Structures
5 records of Q01118 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7TJ8 | Cryo-EM structure of the human Nax channel in complex with beta3 solved in nanodiscs | electron microscopy | A | PEV, POV, PLM, NAG, CLR | 20 (best 0.77) |
| 7TJ8 | Cryo-EM structure of the human nax channel in complex with BETA3 solved in nanodiscs | electron microscopy | A | PEV, POV, PLM, NAG, CLR | — |
| 7TJ9 | Cryo-EM structure of the human Nax channel in complex with beta3 solved in GDN | electron microscopy | A | NAG, PEV, POV, PLM, CLR, Q7G | 20 (best 0.85) |
| 7TJ9 | Cryo-EM structure of the human nax channel in complex with BETA3 solved in gdn | electron microscopy | A | NAG, PEV, POV, PLM, CLR, Q7G | — |
| Q01118 | AlphaFold monomer V2.0 prediction for sodium channel protein type 7 subunit alpha (Q01118) | predicted | A | — | 20 (best 0.86) |
Ligands
- CLR · Cholesterol · in 4 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
- PEV · (1S)-2-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate · in 4 records
- PLM · Palmitic acid · in 4 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 4 records
- Q7G · 2-{[(4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranosyl)oxy]methyl}-4-{[(3beta,9beta,14beta, 17beta,25r)-spirost-5-en-3-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside · in 2 records
Experiment against prediction
- 7TJ9 chain A against the predicted model Q01118: TM-score 0.98, RMSD 1.59 Å
- 7TJ9 chain A against the predicted model Q01118: TM-score 0.98, RMSD 1.59 Å
- 7TJ8 chain A against the predicted model Q01118: TM-score 0.97, RMSD 1.75 Å
- 7TJ8 chain A against the predicted model Q01118: TM-score 0.97, RMSD 1.75 Å
Elsewhere
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