Research workbench
Head region of a complex of igf-I with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor
Analyse Head region of a complex of igf-I with the ectodomain of a hybrid insulin… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7S0Q
- Type
- protein
- Length
- 958 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin-like growth factor 1 receptor; Insulin receptor; Insulin-like growth factor I
- EC
- 2.7.10.1
- UniProt
- P08069, P06213, P05019
- Ligands
- NAG, BMA
- Pockets
- 11 · best druggability 0.84
Structure
electron microscopy · 3 distinct chains · 14% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin-like growth factor 1 receptor (EC 2.7.10.1) | protein | 575 | 10% helix, 27% strand | P08069 |
| B | Insulin receptor (EC 2.7.10.1) | protein | 322 | 18% helix, 28% strand | P06213 |
| D | Insulin-like growth factor I | protein | 61 | 39% helix, 3% strand | P05019 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 13 copies · chains A, B
- BMA · beta-D-mannopyranose · sugar · 3 copies
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1176 | 0.84 | 0.85 | 100 | empty |
| 2 | 566 | 0.83 | 0.88 | 48 | empty |
| 3 | 349 | 0.75 | 0.86 | 52 | empty |
| 4 | 224 | 0.53 | 0.77 | 41 | empty |
| 5 | 84 | 0.50 | 0.84 | 22 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1852 Ų buried · 18 hydrogen bonds · protein-protein
- A–D · 1162 Ų buried · 21 hydrogen bonds · protein-protein
- B–D · 1008 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 21 disulfide, 10 glycan (disulfide, N-glycosylation).
Compared structures
- 7S0Q · Head region of a complex of IGF-I with the ectodomain of a hybrid insulin receptor / type… · the same entry in another collection · chain A against A, TM-score 1.00
- P05019 · AlphaFold monomer V2.0 prediction for insulin-like growth factor I (P05019) · a predicted model of the same protein · chain D against A, TM-score 0.61
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08069
- Every structure of UniProt P06213
- Every structure of UniProt P05019
- Elsewhere: RCSB PDB 7S0Q · PDBe 7S0Q · UniProt P08069 · UniProt P06213 · UniProt P05019
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