UniProt P05019
Insulin-like growth factor I (P05019)
Insulin-like growth factor I (UniProt P05019): 34 experimental structures and 1 predicted model on GenesisL1, 42 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P05019
- Protein
- Insulin-like growth factor I
- Experimental structures
- 34
- Predicted models
- 1
- Pockets
- 42 · 9 records with a druggable one
Structures
35 records of P05019 in the MolNFT archive: 34 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BQT | Three-dimensional structure of human insulin-like growth factor-I (igf-I) determined by 1H-NMR and… | solution nmr | A | — | — |
| 1BQT | Three-dimensional structure of human insulin-like growth factor-I (igf-I) determined by 1H-NMR and… | solution nmr | A | — | — |
| 1PMX | Insulin-like growth factor-I bound to a phage-derived peptide | solution nmr | A | — | — |
| 1PMX | Insulin-like growth factor-I bound to a phage-derived peptide | solution nmr | A | — | — |
| 1WQJ | Structural Basis for the Regulation of Insulin-Like Growth Factors (IGFs) by IGF Binding Proteins… | x-ray diffraction | I | — | — |
| 1WQJ | Structural basis for the regulation of insulin-like growth factors (igfs) by igf binding proteins… | x-ray diffraction | I | — | — |
| 2DSP | Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins | x-ray diffraction | I | — | — |
| 2DSP | Structural basis for the inhibition of insulin-like growth factors by igf binding proteins | x-ray diffraction | I | — | — |
| 2DSQ | Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins | x-ray diffraction | I, C | — | — |
| 2DSQ | Structural basis for the inhibition of insulin-like growth factors by igf binding proteins | x-ray diffraction | I, C | — | — |
| 2DSR | Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins | x-ray diffraction | I | — | — |
| 2DSR | Structural basis for the inhibition of insulin-like growth factors by igf binding proteins | x-ray diffraction | I | — | — |
| 3LRI | Solution structure and backbone dynamics of long-[Arg(3)]insulin-like growth factor-I | solution nmr | A | — | — |
| 3LRI | Solution structure and backbone dynamics of long-[ARG(3)]INSULIN-like growth factor-I | solution nmr | A | — | — |
| 4XSS | Insulin-like growth factor I in complex with site 1 of a hybrid insulin receptor / Type 1… | x-ray diffraction | B | — | — |
| 4XSS | Insulin-like growth factor I in complex with site 1 of a hybrid insulin receptor / type 1… | x-ray diffraction | B | — | — |
| 5U8Q | Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor in complex with… | x-ray diffraction | B | — | — |
| 5U8Q | Structure of the ectodomain of the human type 1 insulin-like growth factor receptor in complex with… | x-ray diffraction | B | — | — |
| 6FF3 | Crystal structure of Drosophila neural ectodermal development factor Imp-L1 with Human IGF-I | x-ray diffraction | B | — | 1 (best 0.65) |
| 6FF3 | Crystal structure of drosophila neural ectodermal development factor imp-L1 with human igf-I | x-ray diffraction | B | — | — |
| 6PYH | Cryo-EM structure of full-length IGF1R-IGF1 complex. Only the extracellular region of the complex… | electron microscopy | B | — | — |
| 6PYH | Cryo-EM structure of full-length IGF1R-IGF1 complex. only the extracellular region of the complex… | electron microscopy | B | — | — |
| 6RVA | Structure of [ASP58]-igf-I analogue | solution nmr | X | — | — |
| 6RVA | Structure of [ASP58]-igf-I analogue | solution nmr | X | — | — |
| 7S0Q | Head region of a complex of igf-I with the ectodomain of a hybrid insulin receptor / type 1… | electron microscopy | D | — | — |
| 7WRQ | Structure of Human IGF1/IGFBP3/ALS Ternary Complex | electron microscopy | C | — | 7 (best 0.79) |
| 7WRQ | Structure of human IGF1/IGFBP3/ALS ternary complex | electron microscopy | C | — | — |
| 7YRR | Cryo-EM structure of IGF1R with two IGF1 complex | electron microscopy | C, D | — | 2 (best 0.64) |
| 8EYR | Cryo-EM structure of two IGF1 bound full-length mouse IGF1R mutant (four glycine residues inserted… | electron microscopy | C, D | — | 5 (best 0.82) |
| 8X06 | Cryo-EM structure of the IR/IGF-I complex, conformation 1 | electron microscopy | C, D | — | 5 (best 0.70) |
| 8X2M | Cryo-EM structure of the IR/IGF-I complex, conformation 2 | electron microscopy | C, D, E, F | — | 7 (best 0.71) |
| 8XJS | Cryo-EM structure of human insulin receptor bound to 3 IGF-I | electron microscopy | D, C, E | — | 2 (best 0.77) |
| 8XK1 | Cryo-EM structure of human insulin receptor bound to 4 IGF-I | electron microscopy | C, D, E, F | — | 8 (best 0.69) |
| 8XKM | Cryo-EM structure of human insulin receptor bound to 4 IGF-I, conformation 3 | electron microscopy | C, E, F, D | — | 5 (best 0.78) |
| P05019 | AlphaFold monomer V2.0 prediction for insulin-like growth factor I (P05019) | predicted | A | — | — |
Experiment against prediction
- 2DSQ chain I against the predicted model P05019: TM-score 0.84, RMSD 1.42 Å
- 2DSQ chain I against the predicted model P05019: TM-score 0.84, RMSD 1.42 Å
- 8XJS chain D against the predicted model P05019: TM-score 0.83, RMSD 0.23 Å
- 2DSQ chain C against the predicted model P05019: TM-score 0.81, RMSD 1.66 Å
- 2DSQ chain C against the predicted model P05019: TM-score 0.81, RMSD 1.66 Å
- 2DSP chain I against the predicted model P05019: TM-score 0.80, RMSD 1.89 Å
- 2DSP chain I against the predicted model P05019: TM-score 0.80, RMSD 1.89 Å
- 4XSS chain B against the predicted model P05019: TM-score 0.78, RMSD 1.84 Å
- 4XSS chain B against the predicted model P05019: TM-score 0.78, RMSD 1.84 Å
- 8X2M chain C against the predicted model P05019: TM-score 0.77, RMSD 1.89 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.