UniProt P06213
Isoform Short of Insulin receptor (P06213)
Isoform Short of Insulin receptor (UniProt P06213), EC 2.7.10.1: 116 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 487 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P06213
- Protein
- Isoform Short of Insulin receptor
- EC
- 2.7.10.1
- Experimental structures
- 116
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 487 · 30 records with a druggable one
Structures
117 records of P06213 in the MolNFT archive: 116 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1GAG | Crystal structure of the insulin receptor kinase in complex with a bisubstrate inhibitor | x-ray diffraction | A | — | — |
| 1GAG | Crystal structure of the insulin receptor kinase in complex with a bisubstrate inhibitor | x-ray diffraction | A | — | — |
| 1I44 | Crystallographic studies of an activation loop mutant of the insulin receptor tyrosine kinase | x-ray diffraction | A | — | — |
| 1I44 | Crystallographic studies of an activation loop mutant of the insulin receptor tyrosine kinase | x-ray diffraction | A | — | — |
| 1IR3 | Phosphorylated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog | x-ray diffraction | A | — | — |
| 1IR3 | Phosphorylated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog | x-ray diffraction | A | — | — |
| 1IRK | Crystal structure of the tyrosine kinase domain of the human insulin receptor | x-ray diffraction | A | — | — |
| 1IRK | Crystal structure of the tyrosine kinase domain of the human insulin receptor | x-ray diffraction | A | — | — |
| 1P14 | Crystal structure of a catalytic-loop mutant of the insulin receptor tyrosine kinase | x-ray diffraction | A | — | — |
| 1P14 | Crystal structure of a catalytic-loop mutant of the insulin receptor tyrosine kinase | x-ray diffraction | A | — | — |
| 1RQQ | Crystal Structure of the Insulin Receptor Kinase in Complex with the SH2 Domain of APS | x-ray diffraction | A, B | — | — |
| 1RQQ | Crystal structure of the insulin receptor kinase in complex with the SH2 domain of aps | x-ray diffraction | A, B | — | — |
| 2AUH | Crystal structure of the Grb14 BPS region in complex with the insulin receptor tyrosine kinase | x-ray diffraction | A | — | — |
| 2AUH | Crystal structure of the GRB14 bps region in complex with the insulin receptor tyrosine kinase | x-ray diffraction | A | — | — |
| 2B4S | Crystal structure of a complex between PTP1B and the insulin receptor tyrosine kinase | x-ray diffraction | B, D | — | — |
| 2B4S | Crystal structure of a complex between PTP1B and the insulin receptor tyrosine kinase | x-ray diffraction | B, D | — | — |
| 2HR7 | Insulin receptor (domains 1-3) | x-ray diffraction | A, B | — | — |
| 2HR7 | Insulin receptor (domains 1-3) | x-ray diffraction | A, B | — | — |
| 2MFR | Solution structure of the transmembrane domain of the insulin receptor in micelles | solution nmr | A | — | — |
| 2MFR | Solution structure of the transmembrane domain of the insulin receptor in micelles | solution nmr | A | — | — |
| 2Z8C | Phosphorylated insulin receptor tyrosine kinase in complex with… | x-ray diffraction | A | — | — |
| 2Z8C | Phosphorylated insulin receptor tyrosine kinase in complex with (4… | x-ray diffraction | A | — | — |
| 3BU3 | Crystal structure of the insulin receptor kinase in complex with IRS2 KRLB peptide | x-ray diffraction | A | — | — |
| 3BU3 | Crystal structure of the insulin receptor kinase in complex with IRS2 krlb peptide | x-ray diffraction | A | — | — |
| 3BU5 | Crystal structure of the insulin receptor kinase in complex with IRS2 KRLB peptide and ATP | x-ray diffraction | A | — | — |
| 3BU5 | Crystal structure of the insulin receptor kinase in complex with IRS2 krlb peptide and ATP | x-ray diffraction | A | — | — |
| 3BU6 | Crystal structure of the insulin receptor kinase in complex with IRS2 KRLB phosphopeptide | x-ray diffraction | A | — | — |
| 3BU6 | Crystal structure of the insulin receptor kinase in complex with IRS2 krlb phosphopeptide | x-ray diffraction | A | — | — |
| 3EKK | Insulin receptor kinase complexed with an inhibitor | x-ray diffraction | A | — | — |
| 3EKK | Insulin receptor kinase complexed with an inhibitor | x-ray diffraction | A | — | — |
| 3EKN | Insulin receptor kinase complexed with an inhibitor | x-ray diffraction | A | — | — |
| 3EKN | Insulin receptor kinase complexed with an inhibitor | x-ray diffraction | A | — | — |
| 3ETA | Kinase domain of insulin receptor complexed with a pyrrolo pyridine inhibitor | x-ray diffraction | A, B | — | — |
| 3ETA | Kinase domain of insulin receptor complexed with a pyrrolo pyridine inhibitor | x-ray diffraction | A, B | — | — |
| 3W11 | Insulin receptor ectodomain construct comprising domains L1-CR in complex with human insulin… | x-ray diffraction | E, F | — | — |
| 3W11 | Insulin receptor ectodomain construct comprising domains L1-cr in complex with human insulin… | x-ray diffraction | E, F | — | — |
| 3W12 | Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity… | x-ray diffraction | E, F | — | — |
| 3W12 | Insulin receptor ectodomain construct comprising domains L1-cr in complex with high-affinity… | x-ray diffraction | E, F | — | — |
| 3W13 | Insulin receptor ectodomain construct comprising domains L1-CR in complex with high-affinity… | x-ray diffraction | E, F | — | — |
| 3W13 | Insulin receptor ectodomain construct comprising domains L1-cr in complex with high-affinity… | x-ray diffraction | E, F | — | — |
| 4IBM | Crystal structure of insulin receptor kinase domain in complex with an inhibitor Irfin-1 | x-ray diffraction | A, B | — | — |
| 4IBM | Crystal structure of insulin receptor kinase domain in complex with an inhibitor irfin-1 | x-ray diffraction | A, B | — | — |
| 4OGA | Insulin in complex with Site 1 of the human insulin receptor | x-ray diffraction | E, F | — | — |
| 4OGA | Insulin in complex with site 1 of the human insulin receptor | x-ray diffraction | E, F | — | — |
| 4XLV | Crystal structure of the activated insulin receptor tyrosine kinase dimer | x-ray diffraction | A | ACP, MG | 5 (best 0.64) |
| 4XLV | Crystal structure of the activated insulin receptor tyrosine kinase dimer | x-ray diffraction | A | — | — |
| 4XSS | Insulin-like growth factor I in complex with site 1 of a hybrid insulin receptor / Type 1… | x-ray diffraction | E | NAG, FUC, SO4 | 5 (best 0.53) |
| 4XSS | Insulin-like growth factor I in complex with site 1 of a hybrid insulin receptor / type 1… | x-ray diffraction | E | — | — |
| 4XST | Structure of the endoglycosidase-H treated L1-CR domains of the human insulin receptor in complex… | x-ray diffraction | E | — | — |
| 4XST | Structure of the endoglycosidase-H treated L1-cr domains of the human insulin receptor in complex… | x-ray diffraction | E | — | — |
| 4ZXB | Structure of the human insulin receptor ectodomain, irdeltabeta construct, in complex with four Fab… | x-ray diffraction | E | — | — |
| 5E1S | The Crystal structure of INSR Tyrosine Kinase in complex with the Inhibitor BI 885578 | x-ray diffraction | A | 5JA | — |
| 5E1S | The crystal structure of insr tyrosine kinase in complex with the inhibitor bi 885578 | x-ray diffraction | A | — | — |
| 5HHW | Crystal structure of insulin receptor kinase domain in complex with… | x-ray diffraction | A | 60O | — |
| 5HHW | Crystal structure of insulin receptor kinase domain in complex with… | x-ray diffraction | A | — | — |
| 5J3H | Human insulin receptor domains L1-CR in complex with peptide S519C16 and 83-7 Fv | x-ray diffraction | E | NAG, FUC | 5 (best 0.47) |
| 5J3H | Human insulin receptor domains L1-cr in complex with peptide S519C16 and 83-7 fv | x-ray diffraction | E | — | — |
| 5KQV | Insulin receptor ectodomain construct comprising domains L1,CR,L2, FnIII-1 and alphaCT peptide in… | x-ray diffraction | E, F | NAG, FUC | 14 (best 0.86) |
| 5KQV | Insulin receptor ectodomain construct comprising domains L1,CR,L2, fniii-1 and alphact peptide in… | x-ray diffraction | E, F | NAG, FUC | — |
| 5U1M | Structure of the IRS-1 PTB Domain Bound to the Juxtamembrane Region of the Insulin Receptor | x-ray diffraction | B | — | — |
57 records more on the page itself.
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 24 records
- FUC · alpha-L-fucopyranose · in 14 records
- SO4 · Sulfate ion · in 4 records
- 5JA · (5R)-N-(1-{2-[4-(2-methoxyethyl)piperazin-1-yl]ethyl}-1H-pyrazol-3-yl)-5,8-dimethyl-9-phenyl-6,8-dihydro-5H-pyrazolo[3,4-h]quinazolin-2-amine · in 1 record
- 60O · 7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2~{R})-oxan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amine · in 1 record
- ACE · Acetyl group · in 1 record
- ACP · Phosphomethylphosphonic acid adenylate ester · in 1 record
- MAN · alpha-D-mannopyranose · in 1 record
- MG · Magnesium ion · in 1 record
Experiment against prediction
- 5J3H chain E against the predicted model P06213: TM-score 0.99, RMSD 0.44 Å
- 5J3H chain E against the predicted model P06213: TM-score 0.99, RMSD 0.44 Å
- 7KD6 chain K against the predicted model P06213: TM-score 0.99, RMSD 0.50 Å
- 6VEP chain K against the predicted model P06213: TM-score 0.99, RMSD 0.56 Å
- 6VEP chain K against the predicted model P06213: TM-score 0.99, RMSD 0.56 Å
- 6VEP chain W against the predicted model P06213: TM-score 0.99, RMSD 0.60 Å
- 6VEP chain W against the predicted model P06213: TM-score 0.99, RMSD 0.60 Å
- 6VEP chain E against the predicted model P06213: TM-score 0.99, RMSD 0.63 Å
- 6VEP chain E against the predicted model P06213: TM-score 0.99, RMSD 0.63 Å
- 7KD6 chain Q against the predicted model P06213: TM-score 0.99, RMSD 0.66 Å
Elsewhere
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