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Structure of the human inner kinetochore ccan complex

Analyse Structure of the human inner kinetochore ccan complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7QOO
Type: protein
Length: 2,973 residues
Chains: 15
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Centromere protein C; Centromere protein H; Centromere protein I; Centromere protein K…
UniProt: Q03188, Q9H3R5, Q92674, Q9BS16, Q8N0S6, Q9NSP4, Q96H22, Q9BU64, Q6IPU0, Q71F23, Q7L2Z9, Q13352, Q96BT3, Q5EE01
Pockets: 20 · best druggability 0.80

Structure

electron microscopy · 15 distinct chains · 51% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C	Centromere protein C	protein	4	0% helix, 25% strand	Q03188
H	Centromere protein H	protein	210	83% helix, 0% strand	Q9H3R5
I	Centromere protein I	protein	618	56% helix, 0% strand	Q92674
K	Centromere protein K	protein	253	62% helix, 4% strand	Q9BS16
L	Centromere protein L	protein	306	34% helix, 23% strand	Q8N0S6
M	Centromere protein M	protein	176	31% helix, 17% strand	Q9NSP4
N	Centromere protein N	protein	320	33% helix, 17% strand	Q96H22
O	Centromere protein O	protein	199	35% helix, 23% strand	Q9BU64
P	Centromere protein P	protein	233	35% helix, 30% strand	Q6IPU0
U	Centromere protein U	protein	186	75% helix, 0% strand	Q71F23
Q	Centromere protein Q	protein	209	58% helix, 1% strand	Q7L2Z9
R	Centromere protein R	protein	64	61% helix, 0% strand	Q13352
T	Centromere protein T	protein	108	65% helix, 2% strand	Q96BT3
W	Centromere protein W	protein	72	65% helix, 3% strand	Q5EE01
X	Unknown protein	protein	15	87% helix, 0% strand	—

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	546	0.80	0.87	46	empty
2	1032	0.80	0.81	87	empty
3	1010	0.78	0.80	109	empty
4	690	0.78	0.83	71	empty
5	331	0.76	0.87	41	empty

Interfaces

30 interfaces between chains.

H–K · 5485 Å² buried · 12 hydrogen bonds · protein-protein
U–Q · 4050 Å² buried · 17 hydrogen bonds · protein-protein
H–I · 3578 Å² buried · 25 hydrogen bonds · protein-protein
T–W · 2481 Å² buried · 17 hydrogen bonds · protein-protein
P–U · 1984 Å² buried · 22 hydrogen bonds · protein-protein

Compared structures

7QOO · Structure of the human inner kinetochore CCAN complex · the same entry in another collection · chain Q against Q, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q03188
Every structure of UniProt Q9H3R5
Every structure of UniProt Q92674
Every structure of UniProt Q9BS16
Every structure of UniProt Q8N0S6
Every structure of UniProt Q9NSP4
Every structure of UniProt Q96H22
Every structure of UniProt Q9BU64
Every structure of UniProt Q6IPU0
Every structure of UniProt Q71F23
Every structure of UniProt Q7L2Z9
Every structure of UniProt Q13352
Every structure of UniProt Q96BT3
Every structure of UniProt Q5EE01
Elsewhere: RCSB PDB 7QOO · PDBe 7QOO · UniProt Q03188 · UniProt Q9H3R5 · UniProt Q92674 · UniProt Q9BS16 · UniProt Q8N0S6 · UniProt Q9NSP4 · UniProt Q96H22 · UniProt Q9BU64 · UniProt Q6IPU0 · UniProt Q71F23 · UniProt Q7L2Z9 · UniProt Q13352 · UniProt Q96BT3 · UniProt Q5EE01

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