Research workbench
Cryo-EM structure of human full-length extrasynaptic ALPHA4BETA3DELTA GABA(A)R in complex with nanobody NB25
Analyse Cryo-EM structure of human full-length extrasynaptic ALPHA4BETA3DELTA GABA(A)R… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7QN5
- Type
- protein
- Length
- 1,881 residues
- Chains
- 7
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P48169, P28472, O14764
- Ligands
- D10, PX6, NAG, MAN, BMA, CL
Structure
electron microscopy · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 335 | — | P48169 |
| B, C, D | — | protein | 327 | — | P28472 |
| E | — | protein | 323 | — | O14764 |
| F, G | — | protein | 121 | — | — |
Ligands and binding sites
- D10 · Decane · ligand · 2 copies · chains A, B, E
- PX6 · 1,2-dipalmitoyl-sn-glycero-3-phosphate · ligand · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 17 copies · chains A, B, C, F, D, G, E
- MAN · alpha-D-mannopyranose · sugar · 8 copies · chains C, B, F, G
- BMA · beta-D-mannopyranose · sugar · 4 copies · chains B, C, D
- CL · Chloride ion · ion · 3 copies · chains C, D, B, E
- OCT · N-octane · additive · 2 copies · chains A, E
- EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid · additive · 2 copies · chains B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7QN5 · Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex… · the same entry in another collection · chain G against G, TM-score 1.00
- P28472 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit beta-3… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P48169 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit alpha-4… · a predicted model of the same protein · chain A against A, TM-score 0.98
- O14764 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit delta… · a predicted model of the same protein · chain E against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P48169
- Every structure of UniProt P28472
- Every structure of UniProt O14764
- Elsewhere: RCSB PDB 7QN5 · PDBe 7QN5 · UniProt P48169 · UniProt P28472 · UniProt O14764
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