Research workbench
Crystal structure of human UBA6 in complex with the ubiquitin-like modifier FAT10
Analyse Crystal structure of human UBA6 in complex with the ubiquitin-like modifier… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7PYV
- Type
- protein
- Length
- 2,092 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin-like modifier-activating enzyme 6,UBIQUITIN-like modifier-activating enzyme…
- EC
- 6.2.1.45
- UniProt
- A0AVT1, P22314, A0A1U9X8S9
- Pockets
- 20 · best druggability 0.79
Structure
x-ray diffraction · 3 distinct chains · 40% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin-like modifier-activating enzyme 6,UBIQUITIN-like modifier-activating enzyme 1,UBIQUITIN-like modifier-activating enzyme 6 (EC 6.2.1.45) | protein | 967 | 42% helix, 16% strand | A0AVT1, P22314 |
| C | Ubd | protein | 154 | 19% helix, 34% strand | A0A1U9X8S9 |
| B | Ubiquitin-like modifier-activating enzyme 6,UBIQUITIN-like modifier-activating enzyme 1,UBIQUITIN-like modifier-activating enzyme 6 (EC 6.2.1.45) | protein | 971 | 42% helix, 16% strand | A0AVT1, P22314 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1117 | 0.79 | 0.80 | 133 | empty |
| 2 | 1146 | 0.78 | 0.80 | 91 | empty |
| 3 | 1016 | 0.78 | 0.80 | 90 | empty |
| 4 | 1077 | 0.78 | 0.80 | 113 | empty |
| 5 | 55 | 0.71 | 0.98 | 22 | empty |
Interfaces
2 interfaces between chains.
- A–C · 1871 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 831 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 7PYV · Crystal structure of human UBA6 in complex with the ubiquitin-like modifier FAT10 · the same entry in another collection · chain A against A, TM-score 1.00
- A0AVT1 · AlphaFold monomer V2.0 prediction for ubiquitin-like modifier- activating enzyme 6… · a predicted model of the same protein · chain A against A, TM-score 0.80
- P22314 · AlphaFold monomer V2.0 prediction for ubiquitin-like modifier- activating enzyme 1… · a predicted model of the same protein · chain A against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0AVT1
- Every structure of UniProt P22314
- Every structure of UniProt A0A1U9X8S9
- Elsewhere: RCSB PDB 7PYV · PDBe 7PYV · UniProt A0AVT1 · UniProt P22314 · UniProt A0A1U9X8S9
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