MolNFT v1 · #485179 · protein
AlphaFold monomer V2.0 prediction for ubiquitin-like modifier- activating enzyme 1 (P22314)
P22314 · Ubiquitin-like modifier-activating enzyme 1: “AlphaFold monomer V2.0 prediction for ubiquitin-like modifier- activating enzyme 1 (P22314)”. 14 pockets (best druggability 0.72). MolNFT v1 #485179 on GenesisL1: 3D structure, binding…
- Accession
- P22314
- Type
- protein
- Length
- 1,058 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x4d07E6a23DeB6B95bd9b90EcB67368b7e8D3B77e
- Molecule
- Ubiquitin-like modifier-activating enzyme 1
- UniProt
- P22314
- Pockets
- 14 · best druggability 0.72
Structure
1 distinct chain · 40% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin-like modifier-activating enzyme 1 | protein | 1058 | 40% helix, 17% strand | P22314 |
Pockets
14 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 484 | 0.72 | 0.82 | 61 | empty |
| 2 | 462 | 0.60 | 0.75 | 49 | empty |
| 3 | 437 | 0.60 | 0.75 | 41 | empty |
| 4 | 353 | 0.60 | 0.77 | 50 | empty |
| 5 | 363 | 0.57 | 0.75 | 40 | empty |
Compared structures
- 6DC6 · Crystal structure of human ubiquitin activating enzyme E1 (Uba1) in complex with ubiquitin · an experimental structure of the same protein · chain A against A, TM-score 0.93
- 6DC6 · Crystal structure of human ubiquitin activating enzyme E1 (UBA1) in complex with ubiquitin · an experimental structure of the same protein · chain A against A, TM-score 0.93
- 7PYV · Crystal structure of human UBA6 in complex with the ubiquitin-like modifier FAT10 · an experimental structure of the same protein · chain A against B, TM-score 0.73
- 7PYV · Crystal structure of human UBA6 in complex with the ubiquitin-like modifier FAT10 · an experimental structure of the same protein · chain A against B, TM-score 0.73
- 4P22 · Crystal structure of N-terminal fragments of E1 · an experimental structure of the same protein · chain A against B, TM-score 0.29
- 4P22 · Crystal Structure of N-terminal Fragments of E1 · an experimental structure of the same protein · chain A against B, TM-score 0.29
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22314
- Elsewhere: UniProt P22314 · AlphaFold DB P22314
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