MolNFT v1 · #102966 · protein
Crystal structure of N-terminal fragments of E1
4P22 · Ubiquitin-like modifier-activating enzyme 1: “Crystal structure of N-terminal fragments of E1”. X-ray diffraction, 10 pockets (best druggability 0.75). MolNFT v1 #102966 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4P22
- Type
- protein
- Length
- 745 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin-like modifier-activating enzyme 1
- UniProt
- P22314
- Pockets
- 10 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin-like modifier-activating enzyme 1 | protein | 370 | 34% helix, 22% strand | P22314 |
| B | Ubiquitin-like modifier-activating enzyme 1 | protein | 375 | 36% helix, 21% strand | P22314 |
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 565 | 0.75 | 0.82 | 62 | empty |
| 2 | 345 | 0.62 | 0.79 | 47 | empty |
| 3 | 264 | 0.58 | 0.78 | 30 | empty |
| 4 | 319 | 0.58 | 0.77 | 49 | empty |
| 5 | 195 | 0.51 | 0.77 | 38 | empty |
Interfaces
1 interface between chains.
- A–B · 2585 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22314
- Elsewhere: RCSB PDB 4P22 · PDBe 4P22 · UniProt P22314
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