UniProt P22314
Ubiquitin-like modifier-activating enzyme 1 (P22314)
Ubiquitin-like modifier-activating enzyme 1 (UniProt P22314), EC 6.2.1.45: 5 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 34 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P22314
- Protein
- Ubiquitin-like modifier-activating enzyme 1
- EC
- 6.2.1.45
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 34 · 2 records with a druggable one
Structures
6 records of P22314 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4P22 | Crystal Structure of N-terminal Fragments of E1 | x-ray diffraction | A, B | — | — |
| 4P22 | Crystal structure of N-terminal fragments of E1 | x-ray diffraction | A, B | — | — |
| 6DC6 | Crystal structure of human ubiquitin activating enzyme E1 (Uba1) in complex with ubiquitin | x-ray diffraction | A, C | MG, POP | 20 (best 0.74) |
| 6DC6 | Crystal structure of human ubiquitin activating enzyme E1 (UBA1) in complex with ubiquitin | x-ray diffraction | A, C | MG, POP | — |
| 7PYV | Crystal structure of human UBA6 in complex with the ubiquitin-like modifier FAT10 | x-ray diffraction | A, B | — | — |
| P22314 | AlphaFold monomer V2.0 prediction for ubiquitin-like modifier- activating enzyme 1 (P22314) | predicted | A | — | 14 (best 0.72) |
Ligands
Experiment against prediction
- 6DC6 chain A against the predicted model P22314: TM-score 0.99, RMSD 0.80 Å
- 6DC6 chain A against the predicted model P22314: TM-score 0.99, RMSD 0.80 Å
- 6DC6 chain C against the predicted model P22314: TM-score 0.98, RMSD 1.54 Å
- 6DC6 chain C against the predicted model P22314: TM-score 0.98, RMSD 1.54 Å
- 7PYV chain A against the predicted model P22314: TM-score 0.79, RMSD 4.76 Å
- 7PYV chain B against the predicted model P22314: TM-score 0.79, RMSD 4.78 Å
- 4P22 chain A against the predicted model P22314: TM-score 0.79, RMSD 3.09 Å
- 4P22 chain A against the predicted model P22314: TM-score 0.79, RMSD 3.09 Å
- 4P22 chain B against the predicted model P22314: TM-score 0.78, RMSD 3.80 Å
- 4P22 chain B against the predicted model P22314: TM-score 0.78, RMSD 3.80 Å
Elsewhere
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