Research workbench

Human deptor in a complex with mutant human MTORC1 A1459P

Analyse Human deptor in a complex with mutant human MTORC1 A1459P in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7OWG
Type: protein
Length: 3,594 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase mtor; Target of rapamycin complex subunit LST8; Dep…
EC: 2.7.11.1
UniProt: P42345, Q9BVC4, Q8TB45, Q8N122
Pockets: 20 · best druggability 0.81

Structure

electron microscopy · 4 distinct chains · 54% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	SERINE/THREONINE-protein kinase mtor (EC 2.7.11.1)	protein	2152	71% helix, 2% strand	P42345
E	Target of rapamycin complex subunit LST8	protein	317	2% helix, 48% strand	Q9BVC4
O	Dep domain-containing mtor-interacting protein	protein	81	15% helix, 43% strand	Q8TB45
Y	Regulatory-associated protein of mtor	protein	1044	40% helix, 18% strand	Q8N122

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1070	0.81	0.82	83	empty
2	1040	0.81	0.82	97	empty
3	1144	0.80	0.81	61	empty
4	113	0.78	0.96	30	empty
5	84	0.74	0.96	27	empty

Interfaces

3 interfaces between chains.

B–E · 779 Å² buried · 8 hydrogen bonds · protein-protein
B–Y · 776 Å² buried · 10 hydrogen bonds · protein-protein
B–O · 625 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

7OWG · human DEPTOR in a complex with mutant human mTORC1 A1459P · the same entry in another collection · chain Y against Y, TM-score 1.00
Q8N122 · AlphaFold monomer V2.0 prediction for regulatory-associated protein of mtor (Q8N122) · a predicted model of the same protein · chain Y against A, TM-score 0.95
Q9BVC4 · AlphaFold monomer V2.0 prediction for target of rapamycin complex subunit LST8 (Q9BVC4) · a predicted model of the same protein · chain E against A, TM-score 0.94
Q8TB45 · AlphaFold monomer V2.0 prediction for dep domain-containing mtor- interacting protein… · a predicted model of the same protein · chain O against A, TM-score 0.88
P42345 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase mtor (P42345) · a predicted model of the same protein · chain B against A, TM-score 0.84

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P42345
Every structure of UniProt Q9BVC4
Every structure of UniProt Q8TB45
Every structure of UniProt Q8N122
Elsewhere: RCSB PDB 7OWG · PDBe 7OWG · UniProt P42345 · UniProt Q9BVC4 · UniProt Q8TB45 · UniProt Q8N122

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