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UniProt Q8N122

Regulatory-associated protein of mTOR (Q8N122)

Regulatory-associated protein of mTOR (UniProt Q8N122): 27 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 181 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt
Q8N122
Protein
Regulatory-associated protein of mTOR
Experimental structures
27
Predicted models
1
Ligands
1
Pockets
181 · 20 records with a druggable one

Structures

28 records of Q8N122 in the MolNFT archive: 27 experimental, 1 predicted.

EntryTitleMethodChainsLigandsPockets
5H64Cryo-EM structure of mTORC1electron microscopyB, b—8 (best 0.86)
5H64Cryo-EM structure of MTORC1electron microscopyB, b——
6BCUCryo-EM structure of the activated RHEB-mTORC1 refined to 3.4 angstromelectron microscopyW, Y—6 (best 0.86)
6BCXmTORC1 structure refined to 3.0 angstromselectron microscopyW, Y—8 (best 0.85)
6SB0Cryo-EM structure of MTORC1 bound to PRAS40-fused active RAGA/C gtpaseselectron microscopyY, N——
6SB2cryo-EM structure of mTORC1 bound to active RagA/C GTPaseselectron microscopyY, N—8 (best 0.86)
6SB2Cryo-EM structure of MTORC1 bound to active RAGA/C gtpaseselectron microscopyY, N——
6U62Raptor-Rag-Ragulator complexelectron microscopyAGDP12 (best 0.81)
6U62Raptor-rag-ragulator complexelectron microscopyAGDP—
7OWGhuman DEPTOR in a complex with mutant human mTORC1 A1459Pelectron microscopyY—7 (best 0.81)
7OWGHuman deptor in a complex with mutant human MTORC1 A1459Pelectron microscopyY——
7PEAcryo-EM structure of DEPTOR bound to human mTOR complex 1, overall refinementelectron microscopyF, E—7 (best 0.86)
7PEACryo-EM structure of deptor bound to human mtor complex 1, overall refinementelectron microscopyF, E——
7PEBcryo-EM structure of DEPTOR bound to human mTOR complex 1, focussed on one protomerelectron microscopyE—7 (best 0.80)
7PEBCryo-EM structure of deptor bound to human mtor complex 1, focussed on one protomerelectron microscopyE——
7PECcryo-EM structure of DEPTOR bound to human mTOR complex 1, DEPt-bound subset local refinementelectron microscopyE—7 (best 0.81)
7PECCryo-EM structure of deptor bound to human mtor complex 1, dept-bound subset local refinementelectron microscopyE——
7UXCcryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex with symmetry expansionelectron microscopyCGDP8 (best 0.82)
7UXHcryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complexelectron microscopyE, UGDP13 (best 0.84)
8ERARMC-5552 in complex with mTORC1 and FKBP12electron microscopyY—7 (best 0.77)
8RCHCryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in…electron microscopyW, Y—8 (best 0.86)
8RCKCryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in…electron microscopyY—8 (best 0.81)
8RCNCryoEM structure of mTORC1 with a paediatric kidney cancer-associated 1455-EWED-1458 duplication in…electron microscopyY—6 (best 0.77)
9F42cryo-EM structure of LST2 TOS peptide bound to human mTOR complex 1, focused on RAPTORelectron microscopyE—14 (best 0.81)
9F43cryo-EM structure of human LST2 bound to human mTOR complex 1, focused on RAPTORelectron microscopyE—13 (best 0.81)
9F44cryo-EM structure of LST2 TOS peptide bound to human mTOR complex 1electron microscopyE, F—6 (best 0.84)
9F45cryo-EM structure of human LST2 bound to human mTOR complex 1electron microscopyE, F—8 (best 0.85)
Q8N122AlphaFold monomer V2.0 prediction for regulatory-associated protein of mtor (Q8N122)predictedA—20 (best 0.82)

Ligands

  • GDP · Guanosine-5'-diphosphate · in 4 records

Experiment against prediction

Elsewhere

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