Research workbench
Ovine (B0,+AT-RBAT)2 hetero-tetramer, asymmetric unit, rigid-body fitted
Analyse Ovine (B0,+AT-RBAT)2 hetero-tetramer, asymmetric unit, rigid-body fitted in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7NF8
- Type
- protein
- Length
- 1,078 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- B(0,+)-type amino acid transporter 1; Neutral and basic amino acid transport protein rbat
- UniProt
- A0A6P3EL78, A0A6P7DVK7
- Ligands
- CLR, LBN, NAG, CA
- Pockets
- 10 · best druggability 0.75
Structure
electron microscopy · 2 distinct chains · 47% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | B(0,+)-type amino acid transporter 1 | protein | 455 | 73% helix, 1% strand | A0A6P3EL78 |
| A | Neutral and basic amino acid transport protein rbat | protein | 623 | 28% helix, 19% strand | A0A6P7DVK7 |
Ligands and binding sites
- CLR · Cholesterol · ligand · 2 copies · chains B, A
- LBN · 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine · ligand · chains B, A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 8 copies · chains A
- CA · Calcium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 648 | 0.75 | 0.81 | 66 | empty |
| 2 | 346 | 0.74 | 0.85 | 48 | empty |
| 3 | 787 | 0.73 | 0.79 | 80 | empty |
| 4 | 567 | 0.68 | 0.77 | 60 | empty |
| 5 | 150 | 0.47 | 0.77 | 24 | empty |
Interfaces
1 interface between chains.
- B–A · 1614 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 glycan, 4 disulfide (N-glycosylation, disulfide).
Compared structures
- 7NF8 · Ovine (b0,+AT-rBAT)2 hetero-tetramer, asymmetric unit, rigid-body fitted · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A6P3EL78
- Every structure of UniProt A0A6P7DVK7
- Elsewhere: RCSB PDB 7NF8 · PDBe 7NF8 · UniProt A0A6P3EL78 · UniProt A0A6P7DVK7
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