Research workbench
The cbp TAZ1 domain in complex with a CITED2-hif-1-alpha fusion peptide
Analyse The cbp TAZ1 domain in complex with a CITED2-hif-1-alpha fusion peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7LVS
- Type
- protein
- Length
- 155 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone lysine acetyltransferase crebbp; CBP/P300-interacting transactivator…
- EC
- 2.3.1.48, 2.3.1.-
- UniProt
- P45481, Q99967, Q16665
- Ligands
- ZN
- Pockets
- 2 · best druggability 0.54
Structure
x-ray diffraction · 2 distinct chains · 55% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Histone lysine acetyltransferase crebbp (EC 2.3.1.48, 2.3.1.-) | protein | 97 | 60% helix, 0% strand | P45481 |
| F | CBP/P300-interacting transactivator 2,HYPOXIA-inducible factor 1-alpha | protein | 58 | 48% helix, 3% strand | Q99967, Q16665 |
Ligands and binding sites
- ZN · Zinc ion · metal · 3 copies · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 56 | 0.54 | 0.88 | 15 | empty |
| 2 | 60 | 0.35 | 0.78 | 14 | empty |
Interfaces
1 interface between chains.
- B–F · 2419 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 7LVS · The CBP TAZ1 Domain in Complex with a CITED2-HIF-1-Alpha Fusion Peptide · the same entry in another collection · chain B against B, TM-score 1.00
- P45481 · AlphaFold monomer V2.0 prediction for histone lysine acetyltransferase crebbp (P45481) · a predicted model of the same protein · chain B against A, TM-score 0.86
- Q99967 · AlphaFold monomer V2.0 prediction for CBP/P300-interacting transactivator 2 (Q99967) · a predicted model of the same protein · chain F against A, TM-score 0.47
- Q16665 · AlphaFold monomer V2.0 prediction for hypoxia-inducible factor 1-alpha (Q16665) · a predicted model of the same protein · chain F against A, TM-score 0.35
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P45481
- Every structure of UniProt Q99967
- Every structure of UniProt Q16665
- Elsewhere: RCSB PDB 7LVS · PDBe 7LVS · UniProt P45481 · UniProt Q99967 · UniProt Q16665
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