Research workbench
Human tric in ATP/ALFX closed state
Analyse Human tric in ATP/ALFX closed state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7LUM
- Type
- protein
- Length
- 8,374 residues
- Chains
- 16
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- T-complex protein 1 subunit epsilon; T-complex protein 1 subunit beta; T-complex protein…
- UniProt
- P48643, P78371, P50991, P49368, Q99832, P50990, P40227, P17987
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 8 distinct chains · 49% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L, D | T-complex protein 1 subunit epsilon | protein | 527 | 50% helix, 15% strand | P48643 |
| M, E | T-complex protein 1 subunit beta | protein | 518 | 53% helix, 18% strand | P78371 |
| N, F | T-complex protein 1 subunit delta | protein | 518 | 50% helix, 18% strand | P50991 |
| H, P | T-complex protein 1 subunit gamma | protein | 521 | 49% helix, 15% strand | P49368 |
| K, C | T-complex protein 1 subunit eta | protein | 522 | 49% helix, 14% strand | Q99832 |
| J, B | T-complex protein 1 subunit theta | protein | 524 | 48% helix, 14% strand | P50990 |
| I, A | T-complex protein 1 subunit zeta | protein | 525 | 47% helix, 14% strand | P40227 |
| O, G | T-complex protein 1 subunit alpha | protein | 532 | 48% helix, 14% strand | P17987 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1035 | 0.87 | 0.88 | 124 | empty |
| 2 | 960 | 0.86 | 0.88 | 114 | empty |
| 3 | 886 | 0.85 | 0.87 | 120 | empty |
| 4 | 1050 | 0.85 | 0.86 | 120 | empty |
| 5 | 738 | 0.84 | 0.88 | 93 | empty |
Interfaces
51 interfaces between chains.
- H–G · 3778 Ų buried · 72 hydrogen bonds · protein-protein
- P–O · 3682 Ų buried · 67 hydrogen bonds · protein-protein
- L–M · 3648 Ų buried · 49 hydrogen bonds · protein-protein
- D–C · 3623 Ų buried · 49 hydrogen bonds · protein-protein
- D–E · 3585 Ų buried · 46 hydrogen bonds · protein-protein
Compared structures
- 7LUM · Human TRiC in ATP/AlFx closed state · the same entry in another collection · chain I against I, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P48643
- Every structure of UniProt P78371
- Every structure of UniProt P50991
- Every structure of UniProt P49368
- Every structure of UniProt Q99832
- Every structure of UniProt P50990
- Every structure of UniProt P40227
- Every structure of UniProt P17987
- Elsewhere: RCSB PDB 7LUM · PDBe 7LUM · UniProt P48643 · UniProt P78371 · UniProt P50991 · UniProt P49368 · UniProt Q99832 · UniProt P50990 · UniProt P40227 · UniProt P17987
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