Research workbench
Cryo-EM structure of rtx-bound minimal TRPV1 with nmdg at state a
Analyse Cryo-EM structure of rtx-bound minimal TRPV1 with nmdg at state a in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7L2W
- Type
- protein
- Length
- 2,144 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transient receptor potential cation channel subfamily V member 1
- UniProt
- O35433
- Ligands
- 6EU, 6IY, NA
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 1 distinct chain · 57% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D, B, C | Transient receptor potential cation channel subfamily V member 1 | protein | 536 | 57% helix, 4% strand | O35433 |
Ligands and binding sites
- 6EU · resiniferatoxin · ligand · 4 copies · chains A, D, B, C
- 6IY · (10R,13S)-16-amino-13-hydroxy-7,13-dioxo-8,12,14-trioxa-13lambda~5~-phosphahexadecan-10-yl hexadecanoate · ligand · 4 copies · chains A, D, B, C
- NA · Sodium ion · metal · chains A, D, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 966 | 0.82 | 0.83 | 87 | NA |
| 2 | 887 | 0.81 | 0.83 | 75 | empty |
| 3 | 732 | 0.81 | 0.84 | 71 | empty |
| 4 | 704 | 0.80 | 0.84 | 63 | empty |
| 5 | 675 | 0.78 | 0.83 | 61 | empty |
Interfaces
4 interfaces between chains.
- A–B · 2250 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 2217 Ų buried · 9 hydrogen bonds · protein-protein
- D–C · 2195 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 2193 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 7L2W · cryo-EM structure of RTX-bound minimal TRPV1 with NMDG at state a · the same entry in another collection · chain A against A, TM-score 1.00
- O35433 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O35433
- Elsewhere: RCSB PDB 7L2W · PDBe 7L2W · UniProt O35433
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