Research workbench
Cryoem structure of the cgrp receptor with bound cgrp peptide in a detergent micelle
Analyse Cryoem structure of the cgrp receptor with bound cgrp peptide in a detergent… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7KNU
- Type
- protein
- Length
- 467 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Receptor activity-modifying protein 1; Calcitonin gene-related peptide 1; Calcitonin…
- UniProt
- O60894, P06881, Q16602
- Pockets
- 7 · best druggability 0.71
Structure
electron microscopy · 3 distinct chains · 61% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E | Receptor activity-modifying protein 1 | protein | 115 | 63% helix, 0% strand | O60894 |
| P | Calcitonin gene-related peptide 1 | protein | 11 | 0% helix, 0% strand | P06881 |
| R | Calcitonin gene-related peptide type 1 receptor | protein | 341 | 63% helix, 6% strand | Q16602 |
Pockets
7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 466 | 0.71 | 0.81 | 44 | empty |
| 2 | 178 | 0.54 | 0.79 | 26 | empty |
| 3 | 224 | 0.51 | 0.76 | 29 | empty |
| 4 | 122 | 0.51 | 0.81 | 25 | empty |
| 5 | 184 | 0.51 | 0.77 | 23 | empty |
Interfaces
3 interfaces between chains.
- E–R · 2139 Ų buried · 14 hydrogen bonds · protein-protein
- P–R · 564 Ų buried · 10 hydrogen bonds · protein-protein
- E–P · 75 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 7KNU · CryoEM structure of the CGRP receptor with bound CGRP peptide in a detergent micelle · the same entry in another collection · chain E against E, TM-score 1.00
- O60894 · AlphaFold monomer V2.0 prediction for receptor activity-modifying protein 1 (O60894) · a predicted model of the same protein · chain E against A, TM-score 0.94
- Q16602 · AlphaFold monomer V2.0 prediction for calcitonin gene-related peptide type 1 receptor… · a predicted model of the same protein · chain R against A, TM-score 0.80
- P06881 · AlphaFold monomer V2.0 prediction for calcitonin gene-related peptide 1 (P06881) · a predicted model of the same protein · chain P against A, TM-score 0.51
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60894
- Every structure of UniProt P06881
- Every structure of UniProt Q16602
- Elsewhere: RCSB PDB 7KNU · PDBe 7KNU · UniProt O60894 · UniProt P06881 · UniProt Q16602
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