Research workbench
The H/ACA rnp lobe of human telomerase
Analyse The H/ACA rnp lobe of human telomerase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7BGB
- Type
- protein + RNA
- Length
- 1,666 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Telomerase cajal body protein 1; H/ACA ribonucleoprotein complex subunit DKC1; H/ACA…
- EC
- 5.4.99.-
- UniProt
- Q9BUR4, O60832, Q9NPE3, Q9NY12, Q9NX24
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 9 distinct chains · 14% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| K | Telomerase cajal body protein 1 | protein | 313 | 0% helix, 37% strand | Q9BUR4 |
| G | H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) | protein | 339 | 15% helix, 27% strand | O60832 |
| J | H/ACA ribonucleoprotein complex subunit 3 | protein | 64 | 16% helix, 19% strand | Q9NPE3 |
| B | RNA (92-mer) | rna | 92 | — | — |
| H | H/ACA ribonucleoprotein complex subunit 1 | protein | 94 | 6% helix, 43% strand | Q9NY12 |
| I, E | H/ACA ribonucleoprotein complex subunit 2 | protein | 128 | 35% helix, 12% strand | Q9NX24 |
| D | H/ACA ribonucleoprotein complex subunit 1 | protein | 89 | 4% helix, 46% strand | Q9NY12 |
| F | H/ACA ribonucleoprotein complex subunit 3 | protein | 62 | 16% helix, 19% strand | Q9NPE3 |
| C | H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) | protein | 357 | 22% helix, 25% strand | O60832 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1023 | 0.80 | 0.82 | 72 | empty |
| 2 | 1007 | 0.80 | 0.82 | 80 | empty |
| 3 | 616 | 0.79 | 0.85 | 70 | empty |
| 4 | 943 | 0.75 | 0.78 | 71 | empty |
| 5 | 1048 | 0.72 | 0.75 | 83 | empty |
Interfaces
22 interfaces between chains.
- G–B · 2053 Ų buried · 15 hydrogen bonds · protein-nucleic
- G–J · 1736 Ų buried · 6 hydrogen bonds · protein-protein
- F–C · 1600 Ų buried · 12 hydrogen bonds · protein-protein
- G–C · 1405 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 1325 Ų buried · 16 hydrogen bonds · protein-nucleic
Compared structures
- 7BGB · The H/ACA RNP lobe of human telomerase · the same entry in another collection · chain C against C, TM-score 1.00
- Q9BUR4 · AlphaFold monomer V2.0 prediction for telomerase cajal body protein 1 (Q9BUR4) · a predicted model of the same protein · chain K against A, TM-score 0.97
- O60832 · AlphaFold monomer V2.0 prediction for H/ACA ribonucleoprotein complex subunit DKC1… · a predicted model of the same protein · chain G against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BUR4
- Every structure of UniProt O60832
- Every structure of UniProt Q9NPE3
- Every structure of UniProt Q9NY12
- Every structure of UniProt Q9NX24
- Elsewhere: RCSB PDB 7BGB · PDBe 7BGB · UniProt Q9BUR4 · UniProt O60832 · UniProt Q9NPE3 · UniProt Q9NY12 · UniProt Q9NX24
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.