Research workbench
Structure of a mitochondrial calcium uniporter holocomplex (MICU1, MICU2, mcu, emre) in low CA2+
Analyse Structure of a mitochondrial calcium uniporter holocomplex (MICU1, MICU2, mcu… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6XQN
- Type
- protein
- Length
- 1,290 residues
- Chains
- 9
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein emre homolog, mitochondrial-like protein; Calcium uniporter protein; Calcium…
- UniProt
- D6X268, D6WIX5, Q9BPX6, Q8IYU8
- Ligands
- CA
- Pockets
- 15 · best druggability 0.74
Structure
electron microscopy · 7 distinct chains · 70% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E | Protein emre homolog, mitochondrial-like protein | protein | 31 | 94% helix, 0% strand | D6X268 |
| A, C | Calcium uniporter protein | protein | 154 | 86% helix, 0% strand | D6WIX5 |
| B, D | Calcium uniporter protein | protein | 151 | 90% helix, 0% strand | D6WIX5 |
| G | Protein emre homolog, mitochondrial-like protein | protein | 25 | 92% helix, 0% strand | D6X268 |
| H | Protein emre homolog, mitochondrial-like protein | protein | 26 | 92% helix, 0% strand | D6X268 |
| I | Calcium uptake protein 1, mitochondrial | protein | 307 | 56% helix, 6% strand | Q9BPX6 |
| J | Calcium uptake protein 2, mitochondrial | protein | 291 | 59% helix, 3% strand | Q8IYU8 |
Ligands and binding sites
- CA · Calcium ion · metal · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 889 | 0.74 | 0.77 | 59 | empty |
| 2 | 699 | 0.71 | 0.78 | 60 | empty |
| 3 | 105 | 0.71 | 0.92 | 25 | empty |
| 4 | 380 | 0.67 | 0.81 | 46 | empty |
| 5 | 162 | 0.62 | 0.84 | 24 | empty |
Interfaces
18 interfaces between chains.
- A–D · 1694 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 1655 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 1147 Ų buried · 6 hydrogen bonds · protein-protein
- C–D · 1126 Ų buried · 5 hydrogen bonds · protein-protein
- I–J · 862 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 6XQN · Structure of a mitochondrial calcium uniporter holocomplex (MICU1, MICU2, MCU, EMRE) in… · the same entry in another collection · chain J against J, TM-score 1.00
- Q9BPX6 · AlphaFold monomer V2.0 prediction for calcium uptake protein 1, mitochondrial (Q9BPX6) · a predicted model of the same protein · chain I against A, TM-score 0.96
- Q8IYU8 · AlphaFold monomer V2.0 prediction for calcium uptake protein 2, mitochondrial (Q8IYU8) · a predicted model of the same protein · chain J against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt D6X268
- Every structure of UniProt D6WIX5
- Every structure of UniProt Q9BPX6
- Every structure of UniProt Q8IYU8
- Elsewhere: RCSB PDB 6XQN · PDBe 6XQN · UniProt D6X268 · UniProt D6WIX5 · UniProt Q9BPX6 · UniProt Q8IYU8
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