UniProt Q9BPX6
Calcium uptake protein 1, mitochondrial (Q9BPX6)
Calcium uptake protein 1, mitochondrial (UniProt Q9BPX6): 24 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 62 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9BPX6
- Protein
- Calcium uptake protein 1, mitochondrial
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 62 · 8 records with a druggable one
Structures
25 records of Q9BPX6 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4NSC | Crystal Structure of CBARA1 in the Apo-form | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4NSC | Crystal structure of CBARA1 in the apo-form | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4NSD | Crystal Structure of CBARA1 in the Ca2+ Binding Form | x-ray diffraction | A, B | — | — |
| 4NSD | Crystal structure of CBARA1 in the CA2+ binding form | x-ray diffraction | A, B | — | — |
| 6K7Y | Intact human mitochondrial calcium uniporter complex with MICU1/MICU2 subunits | electron microscopy | I, V | — | 6 (best 0.84) |
| 6K7Y | Intact human mitochondrial calcium uniporter complex with MICU1/MICU2 subunits | electron microscopy | I, V | — | — |
| 6LB7 | Crystal structure of the Ca2+-free and Ca2+-bound MICU1-MICU2 complex | x-ray diffraction | A, C | CA | 11 (best 0.78) |
| 6LB7 | Crystal structure of the CA2+-free and CA2+-bound MICU1-MICU2 complex | x-ray diffraction | A, C | CA | — |
| 6LB8 | Crystal structure of the Ca2+-free T4L-MICU1-MICU2 complex | x-ray diffraction | A, C | — | — |
| 6LB8 | Crystal structure of the CA2+-free T4L-MICU1-MICU2 complex | x-ray diffraction | A, C | — | — |
| 6LE5 | Crystal structure of the mitochondrial calcium uptake 1 and 2 heterodimer (MICU1-MICU2 heterodimer)… | x-ray diffraction | A, D, E, G | — | — |
| 6LE5 | Crystal structure of the mitochondrial calcium uptake 1 and 2 heterodimer (MICU1-MICU2 heterodimer)… | x-ray diffraction | A, D, E, G | — | — |
| 6WDN | Cryo-EM structure of mitochondrial calcium uniporter holocomplex in low Ca2+ | electron microscopy | B | — | 8 (best 0.67) |
| 6WDN | Cryo-EM structure of mitochondrial calcium uniporter holocomplex in low CA2+ | electron microscopy | B | — | — |
| 6WDO | Cryo-EM structure of mitochondrial calcium uniporter holocomplex in high Ca2+ | electron microscopy | Q, S | — | 9 (best 0.82) |
| 6WDO | Cryo-EM structure of mitochondrial calcium uniporter holocomplex in high CA2+ | electron microscopy | Q, S | — | — |
| 6XJV | MCU holocomplex in High-calcium state | electron microscopy | Q, S | — | 7 (best 0.87) |
| 6XJV | Mcu holocomplex in high-calcium state | electron microscopy | Q, S | — | — |
| 6XJX | MCU holocomplex in Low-calcium blocking state | electron microscopy | Q | — | 12 (best 0.80) |
| 6XJX | Mcu holocomplex in low-calcium blocking state | electron microscopy | Q | — | — |
| 6XQN | Structure of a mitochondrial calcium uniporter holocomplex (MICU1, MICU2, MCU, EMRE) in low Ca2+ | electron microscopy | I | — | 5 (best 0.67) |
| 6XQN | Structure of a mitochondrial calcium uniporter holocomplex (MICU1, MICU2, mcu, emre) in low CA2+ | electron microscopy | I | — | — |
| 6XQO | Structure of the human MICU1-MICU2 heterodimer, calcium bound, in association with a lipid nanodisc | electron microscopy | I | CA | 4 (best 0.76) |
| 6XQO | Structure of the human MICU1-MICU2 heterodimer, calcium bound, in association with a lipid nanodisc | electron microscopy | I | CA | — |
| Q9BPX6 | AlphaFold monomer V2.0 prediction for calcium uptake protein 1, mitochondrial (Q9BPX6) | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 4 records
Experiment against prediction
- 6WDN chain B against the predicted model Q9BPX6: TM-score 0.97, RMSD 1.08 Å
- 6WDN chain B against the predicted model Q9BPX6: TM-score 0.97, RMSD 1.08 Å
- 6LE5 chain G against the predicted model Q9BPX6: TM-score 0.97, RMSD 1.10 Å
- 6LE5 chain G against the predicted model Q9BPX6: TM-score 0.97, RMSD 1.10 Å
- 6LB7 chain C against the predicted model Q9BPX6: TM-score 0.97, RMSD 1.32 Å
- 6LB7 chain C against the predicted model Q9BPX6: TM-score 0.97, RMSD 1.32 Å
- 6LE5 chain A against the predicted model Q9BPX6: TM-score 0.96, RMSD 1.14 Å
- 6LE5 chain A against the predicted model Q9BPX6: TM-score 0.96, RMSD 1.14 Å
- 6XQN chain I against the predicted model Q9BPX6: TM-score 0.96, RMSD 1.09 Å
- 6XQN chain I against the predicted model Q9BPX6: TM-score 0.96, RMSD 1.09 Å
Elsewhere
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