UniProt Q8IYU8
Calcium uptake protein 2, mitochondrial (Q8IYU8)
Calcium uptake protein 2, mitochondrial (UniProt Q8IYU8), EC 3.2.1.17: 24 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 77 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q8IYU8
- Protein
- Calcium uptake protein 2, mitochondrial
- EC
- 3.2.1.17
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 77 · 11 records with a druggable one
Structures
25 records of Q8IYU8 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6AGH | Crystal structure of EFHA1 in Apo-State | x-ray diffraction | A, B | — | 9 (best 0.69) |
| 6AGH | Crystal structure of EFHA1 in apo-state | x-ray diffraction | A, B | — | — |
| 6IIH | crystal structure of mitochondrial calcium uptake 2(MICU2) | x-ray diffraction | A, B | CA | 12 (best 0.78) |
| 6IIH | Crystal structure of mitochondrial calcium uptake 2(MICU2) | x-ray diffraction | A, B | CA | — |
| 6K7Y | Intact human mitochondrial calcium uniporter complex with MICU1/MICU2 subunits | electron microscopy | J, W | — | 8 (best 0.84) |
| 6K7Y | Intact human mitochondrial calcium uniporter complex with MICU1/MICU2 subunits | electron microscopy | J, W | — | — |
| 6LB7 | Crystal structure of the Ca2+-free and Ca2+-bound MICU1-MICU2 complex | x-ray diffraction | B, D | CA | 11 (best 0.78) |
| 6LB7 | Crystal structure of the CA2+-free and CA2+-bound MICU1-MICU2 complex | x-ray diffraction | B, D | CA | — |
| 6LB8 | Crystal structure of the Ca2+-free T4L-MICU1-MICU2 complex | x-ray diffraction | B, D | — | — |
| 6LB8 | Crystal structure of the CA2+-free T4L-MICU1-MICU2 complex | x-ray diffraction | B, D | — | — |
| 6LE5 | Crystal structure of the mitochondrial calcium uptake 1 and 2 heterodimer (MICU1-MICU2 heterodimer)… | x-ray diffraction | B, C, F, H | — | — |
| 6LE5 | Crystal structure of the mitochondrial calcium uptake 1 and 2 heterodimer (MICU1-MICU2 heterodimer)… | x-ray diffraction | B, C, F, H | — | — |
| 6WDN | Cryo-EM structure of mitochondrial calcium uniporter holocomplex in low Ca2+ | electron microscopy | A | — | 3 (best 0.73) |
| 6WDN | Cryo-EM structure of mitochondrial calcium uniporter holocomplex in low CA2+ | electron microscopy | A | — | — |
| 6WDO | Cryo-EM structure of mitochondrial calcium uniporter holocomplex in high Ca2+ | electron microscopy | R, T | — | 7 (best 0.82) |
| 6WDO | Cryo-EM structure of mitochondrial calcium uniporter holocomplex in high CA2+ | electron microscopy | R, T | — | — |
| 6XJV | MCU holocomplex in High-calcium state | electron microscopy | R, T | — | 6 (best 0.87) |
| 6XJV | Mcu holocomplex in high-calcium state | electron microscopy | R, T | — | — |
| 6XJX | MCU holocomplex in Low-calcium blocking state | electron microscopy | R | — | 3 (best 0.72) |
| 6XJX | Mcu holocomplex in low-calcium blocking state | electron microscopy | R | — | — |
| 6XQN | Structure of a mitochondrial calcium uniporter holocomplex (MICU1, MICU2, MCU, EMRE) in low Ca2+ | electron microscopy | J | — | 6 (best 0.71) |
| 6XQN | Structure of a mitochondrial calcium uniporter holocomplex (MICU1, MICU2, mcu, emre) in low CA2+ | electron microscopy | J | — | — |
| 6XQO | Structure of the human MICU1-MICU2 heterodimer, calcium bound, in association with a lipid nanodisc | electron microscopy | J | CA | 5 (best 0.76) |
| 6XQO | Structure of the human MICU1-MICU2 heterodimer, calcium bound, in association with a lipid nanodisc | electron microscopy | J | CA | — |
| Q8IYU8 | AlphaFold monomer V2.0 prediction for calcium uptake protein 2, mitochondrial (Q8IYU8) | predicted | A | — | 7 (best 0.71) |
Ligands
- CA · Calcium ion · in 6 records
Experiment against prediction
- 6LE5 chain B against the predicted model Q8IYU8: TM-score 0.95, RMSD 1.50 Å
- 6LE5 chain B against the predicted model Q8IYU8: TM-score 0.95, RMSD 1.50 Å
- 6LE5 chain H against the predicted model Q8IYU8: TM-score 0.94, RMSD 1.60 Å
- 6LE5 chain H against the predicted model Q8IYU8: TM-score 0.94, RMSD 1.60 Å
- 6LE5 chain F against the predicted model Q8IYU8: TM-score 0.94, RMSD 1.63 Å
- 6LE5 chain F against the predicted model Q8IYU8: TM-score 0.94, RMSD 1.63 Å
- 6LE5 chain C against the predicted model Q8IYU8: TM-score 0.94, RMSD 1.63 Å
- 6LE5 chain C against the predicted model Q8IYU8: TM-score 0.94, RMSD 1.63 Å
- 6LB7 chain B against the predicted model Q8IYU8: TM-score 0.94, RMSD 1.80 Å
- 6LB7 chain B against the predicted model Q8IYU8: TM-score 0.94, RMSD 1.80 Å
Elsewhere
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