MolNFT v1 · #152464 · protein
Crystal structure of mitochondrial calcium uptake 2(MICU2)
6IIH · ENDOLYSIN,CALCIUM uptake protein 2, mitochondrial: “Crystal structure of mitochondrial calcium uptake 2(MICU2)”. X-ray diffraction, 1 ligand (CA), 12 pockets (best druggability 0.78). MolNFT v1 #152464 on GenesisL1: 3D structure…
- PDB
- 6IIH
- Type
- protein
- Length
- 883 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ENDOLYSIN,CALCIUM uptake protein 2, mitochondrial
- EC
- 3.2.1.17
- UniProt
- P00720, Q8IYU8
- Ligands
- CA
- Pockets
- 12 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 60% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ENDOLYSIN,CALCIUM uptake protein 2, mitochondrial (EC 3.2.1.17) | protein | 446 | 61% helix, 7% strand | P00720, Q8IYU8 |
| B | ENDOLYSIN,CALCIUM uptake protein 2, mitochondrial (EC 3.2.1.17) | protein | 437 | 58% helix, 7% strand | P00720, Q8IYU8 |
Ligands and binding sites
- CA · Calcium ion · metal · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 990 | 0.78 | 0.80 | 85 | empty |
| 2 | 739 | 0.77 | 0.81 | 63 | empty |
| 3 | 142 | 0.73 | 0.91 | 32 | empty |
| 4 | 256 | 0.58 | 0.79 | 31 | empty |
| 5 | 254 | 0.58 | 0.78 | 34 | empty |
Interfaces
1 interface between chains.
- A–B · 2063 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 6IIH · crystal structure of mitochondrial calcium uptake 2(MICU2) · the same entry in another collection · chain A against A, TM-score 1.00
- Q8IYU8 · AlphaFold monomer V2.0 prediction for calcium uptake protein 2, mitochondrial (Q8IYU8) · a predicted model of the same protein · chain A against A, TM-score 0.62
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00720
- Every structure of UniProt Q8IYU8
- Elsewhere: RCSB PDB 6IIH · PDBe 6IIH · UniProt P00720 · UniProt Q8IYU8
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