MolNFT v1 · #142815 · protein
Crystal structure of EFHA1 in apo-state
6AGH · Calcium uptake protein 2, mitochondrial: “Crystal structure of EFHA1 in apo-state”. X-ray diffraction, 9 pockets (best druggability 0.69). MolNFT v1 #142815 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6AGH
- Type
- protein
- Length
- 555 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calcium uptake protein 2, mitochondrial
- UniProt
- Q8IYU8
- Pockets
- 9 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 61% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calcium uptake protein 2, mitochondrial | protein | 281 | 60% helix, 6% strand | Q8IYU8 |
| B | Calcium uptake protein 2, mitochondrial | protein | 274 | 61% helix, 6% strand | Q8IYU8 |
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 249 | 0.69 | 0.85 | 45 | empty |
| 2 | 239 | 0.69 | 0.85 | 45 | empty |
| 3 | 393 | 0.62 | 0.77 | 37 | empty |
| 4 | 466 | 0.62 | 0.76 | 35 | empty |
| 5 | 425 | 0.60 | 0.75 | 33 | empty |
Interfaces
1 interface between chains.
- A–B · 1319 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IYU8
- Elsewhere: RCSB PDB 6AGH · PDBe 6AGH · UniProt Q8IYU8
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