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Mcu holocomplex in low-calcium blocking state

Analyse Mcu holocomplex in low-calcium blocking state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6XJX
Type: protein
Length: 1,462 residues
Chains: 10
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Calcium uniporter protein, mitochondrial; Essential mcu regulator, mitochondrial; Calcium…
UniProt: Q8NE86, Q9H4I9, Q9BPX6, Q8IYU8
Pockets: 20 · best druggability 0.80

Structure

electron microscopy · 8 distinct chains · 66% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Calcium uniporter protein, mitochondrial	protein	151	83% helix, 0% strand	Q8NE86
B	Essential mcu regulator, mitochondrial	protein	50	52% helix, 4% strand	Q9H4I9
D	Essential mcu regulator, mitochondrial	protein	51	55% helix, 4% strand	Q9H4I9
E	Calcium uniporter protein, mitochondrial	protein	153	85% helix, 0% strand	Q8NE86
F, H	Essential mcu regulator, mitochondrial	protein	49	61% helix, 4% strand	Q9H4I9
G	Calcium uniporter protein, mitochondrial	protein	150	90% helix, 0% strand	Q8NE86
Q	Calcium uptake protein 1, mitochondrial	protein	367	54% helix, 5% strand	Q9BPX6
R	Calcium uptake protein 2, mitochondrial	protein	291	54% helix, 5% strand	Q8IYU8

Pockets

20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	146	0.80	0.96	33	empty
2	668	0.74	0.80	53	empty
3	546	0.72	0.81	56	empty
4	499	0.71	0.81	57	empty
5	692	0.71	0.77	69	empty

Interfaces

22 interfaces between chains.

A–E · 1253 Å² buried · 6 hydrogen bonds · protein-protein
Q–R · 1226 Å² buried · 12 hydrogen bonds · protein-protein
A–C · 1196 Å² buried · 13 hydrogen bonds · protein-protein
C–G · 1184 Å² buried · 8 hydrogen bonds · protein-protein
E–G · 1166 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

6XJX · MCU holocomplex in Low-calcium blocking state · the same entry in another collection · chain R against R, TM-score 1.00
Q8NE86 · AlphaFold monomer V2.0 prediction for calcium uniporter protein, mitochondrial (Q8NE86) · a predicted model of the same protein · chain G against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8NE86
Every structure of UniProt Q9H4I9
Every structure of UniProt Q9BPX6
Every structure of UniProt Q8IYU8
Elsewhere: RCSB PDB 6XJX · PDBe 6XJX · UniProt Q8NE86 · UniProt Q9H4I9 · UniProt Q9BPX6 · UniProt Q8IYU8

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