UniProt Q8NE86
Calcium uniporter protein, mitochondrial (Q8NE86)
Calcium uniporter protein, mitochondrial (UniProt Q8NE86), EC 3.2.1.17: 34 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 109 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q8NE86
- Protein
- Calcium uniporter protein, mitochondrial
- EC
- 3.2.1.17
- Experimental structures
- 34
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 109 · 9 records with a druggable one
Structures
35 records of Q8NE86 in the MolNFT archive: 34 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4XSJ | Crystal structure of the N-terminal domain of the human mitochondrial calcium uniporter fused with… | x-ray diffraction | A | — | — |
| 4XSJ | Crystal structure of the N-terminal domain of the human mitochondrial calcium uniporter fused with… | x-ray diffraction | A | — | — |
| 4XTB | Crystal structure of the N-terminal domain of the human mitochondrial calcium uniporter | x-ray diffraction | A | — | — |
| 4XTB | Crystal structure of the N-terminal domain of the human mitochondrial calcium uniporter | x-ray diffraction | A | — | — |
| 5BZ6 | Crystal structure of the N-terminal domain single mutant (S92A) of the human mitochondrial calcium… | x-ray diffraction | A | SO4 | 2 (best 0.65) |
| 5BZ6 | Crystal structure of the N-terminal domain single mutant (S92A) of the human mitochondrial calcium… | x-ray diffraction | A | — | — |
| 5KUE | Human SeMet incorporated I141M/L146M mitochondrial calcium uniporter (residues 72-189) crystal… | x-ray diffraction | A | MG | — |
| 5KUE | Human semet incorporated I141M/L146M mitochondrial calcium uniporter (residues 72-189) crystal… | x-ray diffraction | A | MG | — |
| 5KUG | Human mitochondrial calcium uniporter (residues 72-189) crystal structure with lithium | x-ray diffraction | A | — | — |
| 5KUG | Human mitochondrial calcium uniporter (residues 72-189) crystal structure with lithium | x-ray diffraction | A | — | — |
| 5KUI | Human mitochondrial calcium uniporter (residues 72-189) crystal structure with calcium. | x-ray diffraction | A | — | — |
| 5KUI | Human mitochondrial calcium uniporter (residues 72-189) crystal structure with calcium. | x-ray diffraction | A | — | — |
| 5KUJ | Human mitochondrial calcium uniporter (residues 72-189) crystal structure with magnesium. | x-ray diffraction | A | MG | — |
| 5KUJ | Human mitochondrial calcium uniporter (residues 72-189) crystal structure with magnesium. | x-ray diffraction | A | MG | — |
| 6JG0 | Crystal structure of the N-terminal domain single mutant (S92E) of the human mitochondrial calcium… | x-ray diffraction | A | SO4 | — |
| 6JG0 | Crystal structure of the N-terminal domain single mutant (S92E) of the human mitochondrial calcium… | x-ray diffraction | A | SO4 | — |
| 6K7X | Human MCU-EMRE complex | electron microscopy | C, A, B, D, K, L, M, N | CDL, PLX, CA | 20 (best 0.82) |
| 6K7X | Human mcu-emre complex | electron microscopy | C, A, B, D, K, L, M, N | CDL, PLX, CA | — |
| 6K7Y | Intact human mitochondrial calcium uniporter complex with MICU1/MICU2 subunits | electron microscopy | A, B, C, D, N, O, P, Q | CA, CDL, PLX | 12 (best 0.86) |
| 6K7Y | Intact human mitochondrial calcium uniporter complex with MICU1/MICU2 subunits | electron microscopy | A, B, C, D, N, O, P, Q | CA, CDL, PLX | — |
| 6KVX | Crystal structure of the N-terminal domain single mutant (D119A) of the human mitochondrial calcium… | x-ray diffraction | A | SO4 | 3 (best 0.59) |
| 6KVX | Crystal structure of the N-terminal domain single mutant (D119A) of the human mitochondrial calcium… | x-ray diffraction | A | SO4 | — |
| 6O58 | Human MCU-EMRE complex, dimer of channel | electron microscopy | K, O, M, G, I, C, A, E | CA | 20 (best 0.75) |
| 6O58 | Human mcu-emre complex, dimer of channel | electron microscopy | K, O, M, G, I, C, A, E | CA | — |
| 6O5B | Monomer of a cation channel | electron microscopy | J, K, E, C, A, L, I, G | CA | — |
| 6O5B | Monomer of a cation channel | electron microscopy | J, K, E, C, A, L, I, G | CA | — |
| 6WDN | Cryo-EM structure of mitochondrial calcium uniporter holocomplex in low Ca2+ | electron microscopy | C, G, I, E | — | 13 (best 0.77) |
| 6WDN | Cryo-EM structure of mitochondrial calcium uniporter holocomplex in low CA2+ | electron microscopy | C, G, I, E | — | — |
| 6WDO | Cryo-EM structure of mitochondrial calcium uniporter holocomplex in high Ca2+ | electron microscopy | G, C, A, E, I, K, O, M | CA | 11 (best 0.83) |
| 6WDO | Cryo-EM structure of mitochondrial calcium uniporter holocomplex in high CA2+ | electron microscopy | G, C, A, E, I, K, O, M | CA | — |
| 6XJV | MCU holocomplex in High-calcium state | electron microscopy | A, C, E, G, I, K, M, O | — | 11 (best 0.75) |
| 6XJV | Mcu holocomplex in high-calcium state | electron microscopy | A, C, E, G, I, K, M, O | — | — |
| 6XJX | MCU holocomplex in Low-calcium blocking state | electron microscopy | A, C, E, G | — | 14 (best 0.74) |
| 6XJX | Mcu holocomplex in low-calcium blocking state | electron microscopy | A, C, E, G | — | — |
| Q8NE86 | AlphaFold monomer V2.0 prediction for calcium uniporter protein, mitochondrial (Q8NE86) | predicted | A | — | 3 (best 0.39) |
Ligands
Experiment against prediction
- 5KUG chain A against the predicted model Q8NE86: TM-score 0.96, RMSD 1.25 Å
- 5KUG chain A against the predicted model Q8NE86: TM-score 0.96, RMSD 1.25 Å
- 5KUE chain A against the predicted model Q8NE86: TM-score 0.96, RMSD 1.28 Å
- 5KUE chain A against the predicted model Q8NE86: TM-score 0.96, RMSD 1.28 Å
- 6O5B chain J against the predicted model Q8NE86: TM-score 0.96, RMSD 0.75 Å
- 6O5B chain J against the predicted model Q8NE86: TM-score 0.96, RMSD 0.75 Å
- 6XJX chain G against the predicted model Q8NE86: TM-score 0.96, RMSD 1.11 Å
- 6XJX chain G against the predicted model Q8NE86: TM-score 0.96, RMSD 1.11 Å
- 5KUJ chain A against the predicted model Q8NE86: TM-score 0.96, RMSD 0.86 Å
- 5KUJ chain A against the predicted model Q8NE86: TM-score 0.96, RMSD 0.86 Å
Elsewhere
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