MolNFT v1 · #110303 · protein
Crystal structure of the N-terminal domain of the human mitochondrial calcium uniporter fused with T4 lysozyme
4XSJ · LYSOZYME,CALCIUM uniporter protein, mitochondrial: “Crystal structure of the N-terminal domain of the human mitochondrial calcium uniporter fused with T4 lysozyme”. X-ray diffraction, 1 ligand (SO4), 3 pockets (best druggability…
- PDB
- 4XSJ
- Type
- protein
- Length
- 253 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- LYSOZYME,CALCIUM uniporter protein, mitochondrial
- EC
- 3.2.1.17
- UniProt
- D9IEF7, Q8NE86
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | LYSOZYME,CALCIUM uniporter protein, mitochondrial (EC 3.2.1.17) | protein | 253 | 46% helix, 19% strand | D9IEF7, Q8NE86 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 468 | 0.62 | 0.76 | 48 | SO4 |
| 2 | 93 | 0.46 | 0.80 | 19 | empty |
| 3 | 114 | 0.42 | 0.77 | 19 | empty |
Compared structures
- 4XSJ · Crystal structure of the N-terminal domain of the human mitochondrial calcium uniporter… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8NE86 · AlphaFold monomer V2.0 prediction for calcium uniporter protein, mitochondrial (Q8NE86) · a predicted model of the same protein · chain A against A, TM-score 0.36
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt D9IEF7
- Every structure of UniProt Q8NE86
- Elsewhere: RCSB PDB 4XSJ · PDBe 4XSJ · UniProt D9IEF7 · UniProt Q8NE86
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