Research workbench

Mcu holocomplex in high-calcium state

Analyse Mcu holocomplex in high-calcium state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6XJV
Type: protein
Length: 3,649 residues
Chains: 20
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Calcium uniporter protein, mitochondrial; Essential mcu regulator, mitochondrial; Calcium…
UniProt: Q8NE86, Q9H4I9, Q9BPX6, Q8IYU8
Pockets: 20 · best druggability 0.87

Structure

electron microscopy · 11 distinct chains · 62% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, I	Calcium uniporter protein, mitochondrial	protein	273	60% helix, 11% strand	Q8NE86
B, J	Essential mcu regulator, mitochondrial	protein	53	55% helix, 4% strand	Q9H4I9
C, K	Calcium uniporter protein, mitochondrial	protein	268	62% helix, 12% strand	Q8NE86
D, L	Essential mcu regulator, mitochondrial	protein	49	59% helix, 4% strand	Q9H4I9
E, M	Calcium uniporter protein, mitochondrial	protein	270	61% helix, 13% strand	Q8NE86
F, N	Essential mcu regulator, mitochondrial	protein	53	55% helix, 4% strand	Q9H4I9
G, O	Calcium uniporter protein, mitochondrial	protein	250	62% helix, 10% strand	Q8NE86
H, P	Essential mcu regulator, mitochondrial	protein	48	56% helix, 4% strand	Q9H4I9
Q	Calcium uptake protein 1, mitochondrial	protein	269	65% helix, 2% strand	Q9BPX6
R, T	Calcium uptake protein 2, mitochondrial	protein	291	60% helix, 4% strand	Q8IYU8
S	Calcium uptake protein 1, mitochondrial	protein	270	65% helix, 3% strand	Q9BPX6

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1113	0.87	0.88	117	empty
2	950	0.86	0.88	93	empty
3	527	0.75	0.83	50	empty
4	754	0.75	0.80	54	empty
5	251	0.74	0.87	44	empty

Interfaces

46 interfaces between chains.

I–M · 2442 Å² buried · 14 hydrogen bonds · protein-protein
A–E · 2442 Å² buried · 13 hydrogen bonds · protein-protein
I–K · 2109 Å² buried · 26 hydrogen bonds · protein-protein
A–C · 2078 Å² buried · 26 hydrogen bonds · protein-protein
M–O · 1733 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

6XJV · MCU holocomplex in High-calcium state · the same entry in another collection · chain R against R, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8NE86
Every structure of UniProt Q9H4I9
Every structure of UniProt Q9BPX6
Every structure of UniProt Q8IYU8
Elsewhere: RCSB PDB 6XJV · PDBe 6XJV · UniProt Q8NE86 · UniProt Q9H4I9 · UniProt Q9BPX6 · UniProt Q8IYU8

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