Research workbench
Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA plus phenobarbital
Analyse Human gabaa receptor ALPHA1-BETA2-GAMMA2 subtype in complex with GABA plus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6X3W
- Type
- protein
- Length
- 2,121 residues
- Chains
- 9
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P47870, P14867, P18507
- Ligands
- ABU, UQA, NAG, MAN, BMA
Structure
electron microscopy · 7 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | — | protein | 334 | — | P47870 |
| B, D | — | protein | 338 | — | P14867 |
| E | — | protein | 333 | — | P18507 |
| I | — | protein | 105 | — | — |
| J | — | protein | 116 | — | — |
| L | — | protein | 106 | — | — |
| K | — | protein | 117 | — | — |
Ligands and binding sites
- ABU · Gamma-amino-butanoic acid · ligand · 2 copies · chains A, B, C, D
- UQA · 5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione · ligand · 2 copies · chains B, C, A, E
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 11 copies · chains A, B, C, E, D
- MAN · alpha-D-mannopyranose · sugar · 7 copies · chains E, D, A
- BMA · beta-D-mannopyranose · sugar · 3 copies · chains E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6X3W · Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus phenobarbital · the same entry in another collection · chain K against K, TM-score 1.00
- P47870 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit beta-2… · a predicted model of the same protein · chain C against A, TM-score 0.99
- P18507 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit gamma-2… · a predicted model of the same protein · chain E against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P47870
- Every structure of UniProt P14867
- Every structure of UniProt P18507
- Elsewhere: RCSB PDB 6X3W · PDBe 6X3W · UniProt P47870 · UniProt P14867 · UniProt P18507
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