Research workbench
The yeast CTF3 complex with CNN1-WIP1
Analyse The yeast CTF3 complex with CNN1-WIP1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6WUC
- Type
- protein
- Length
- 1,266 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Inner kinetochore subunit MCM16; Inner kinetochore subunit CTF3; Inner kinetochore…
- UniProt
- Q12262, Q12748, P47167, Q2V2P8, P43618
- Pockets
- 15 · best druggability 0.81
Structure
electron microscopy · 5 distinct chains · 60% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Inner kinetochore subunit MCM16 | protein | 179 | 70% helix, 0% strand | Q12262 |
| I | Inner kinetochore subunit CTF3 | protein | 713 | 55% helix, 0% strand | Q12748 |
| K | Inner kinetochore subunit MCM22 | protein | 235 | 61% helix, 3% strand | P47167 |
| W | Inner kinetochore subunit WIP1 | protein | 55 | 75% helix, 0% strand | Q2V2P8 |
| T | Inner kinetochore subunit CNN1 | protein | 84 | 71% helix, 0% strand | P43618 |
Pockets
15 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 916 | 0.81 | 0.83 | 87 | empty |
| 2 | 521 | 0.64 | 0.76 | 63 | empty |
| 3 | 424 | 0.61 | 0.76 | 56 | empty |
| 4 | 190 | 0.60 | 0.82 | 35 | empty |
| 5 | 228 | 0.58 | 0.79 | 26 | empty |
Interfaces
8 interfaces between chains.
- H–K · 5109 Ų buried · 28 hydrogen bonds · protein-protein
- H–I · 3987 Ų buried · 41 hydrogen bonds · protein-protein
- I–K · 3111 Ų buried · 32 hydrogen bonds · protein-protein
- W–T · 1824 Ų buried · 4 hydrogen bonds · protein-protein
- I–T · 742 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6WUC · The yeast Ctf3 complex with Cnn1-Wip1 · the same entry in another collection · chain T against T, TM-score 1.00
- P43618 · AlphaFold monomer V2.0 prediction for inner kinetochore subunit CNN1 (P43618) · a predicted model of the same protein · chain T against A, TM-score 0.77
- Q12262 · AlphaFold monomer V2.0 prediction for inner kinetochore subunit MCM16 (Q12262) · a predicted model of the same protein · chain H against A, TM-score 0.74
- Q12748 · AlphaFold monomer V2.0 prediction for inner kinetochore subunit CTF3 (Q12748) · a predicted model of the same protein · chain I against A, TM-score 0.62
- Q2V2P8 · AlphaFold monomer V2.0 prediction for inner kinetochore subunit WIP1 (Q2V2P8) · a predicted model of the same protein · chain W against A, TM-score 0.61
- P47167 · AlphaFold monomer V2.0 prediction for inner kinetochore subunit MCM22 (P47167) · a predicted model of the same protein · chain K against A, TM-score 0.53
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12262
- Every structure of UniProt Q12748
- Every structure of UniProt P47167
- Every structure of UniProt Q2V2P8
- Every structure of UniProt P43618
- Elsewhere: RCSB PDB 6WUC · PDBe 6WUC · UniProt Q12262 · UniProt Q12748 · UniProt P47167 · UniProt Q2V2P8 · UniProt P43618
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.