Research workbench
Cryo-EM structure of SMCR8-C9ORF72-WDR41 complex
Analyse Cryo-EM structure of SMCR8-C9ORF72-WDR41 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6V4U
- Type
- protein
- Length
- 1,106 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Wd repeat-containing protein 41; Guanine nucleotide exchange C9ORF72; Guanine nucleotide…
- UniProt
- Q9HAD4, Q96LT7, Q8TEV9
- Pockets
- 19 · best druggability 0.84
Structure
electron microscopy · 3 distinct chains · 36% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Wd repeat-containing protein 41 | protein | 329 | 2% helix, 18% strand | Q9HAD4 |
| A | Guanine nucleotide exchange C9ORF72 | protein | 356 | 44% helix, 8% strand | Q96LT7 |
| B | Guanine nucleotide exchange protein SMCR8 | protein | 421 | 55% helix, 5% strand | Q8TEV9 |
Pockets
19 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1099 | 0.84 | 0.84 | 129 | empty |
| 2 | 1116 | 0.81 | 0.82 | 131 | empty |
| 3 | 696 | 0.78 | 0.82 | 81 | empty |
| 4 | 459 | 0.75 | 0.84 | 86 | empty |
| 5 | 687 | 0.74 | 0.80 | 95 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1851 Ų buried · 7 hydrogen bonds · protein-protein
- C–B · 807 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6V4U · Cryo-EM structure of SMCR8-C9orf72-WDR41 complex · the same entry in another collection · chain C against C, TM-score 1.00
- Q9HAD4 · AlphaFold monomer V2.0 prediction for wd repeat-containing protein 41 (Q9HAD4) · a predicted model of the same protein · chain C against A, TM-score 0.86
- Q96LT7 · AlphaFold monomer V2.0 prediction for guanine nucleotide exchange C9ORF72 (Q96LT7) · a predicted model of the same protein · chain A against A, TM-score 0.85
- Q8TEV9 · AlphaFold monomer V2.0 prediction for guanine nucleotide exchange protein SMCR8 (Q8TEV9) · a predicted model of the same protein · chain B against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HAD4
- Every structure of UniProt Q96LT7
- Every structure of UniProt Q8TEV9
- Elsewhere: RCSB PDB 6V4U · PDBe 6V4U · UniProt Q9HAD4 · UniProt Q96LT7 · UniProt Q8TEV9
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.