UniProt Q8TEV9
Guanine nucleotide exchange protein SMCR8 (Q8TEV9)
Guanine nucleotide exchange protein SMCR8 (UniProt Q8TEV9): 10 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 59 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q8TEV9
- Protein
- Guanine nucleotide exchange protein SMCR8
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 59 · 6 records with a druggable one
Structures
11 records of Q8TEV9 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6LT0 | cryo-EM structure of C9ORF72-SMCR8-WDR41 | electron microscopy | B, E | — | 13 (best 0.81) |
| 6LT0 | Cryo-EM structure of C9ORF72-SMCR8-WDR41 | electron microscopy | B, E | — | — |
| 6V4U | Cryo-EM structure of SMCR8-C9orf72-WDR41 complex | electron microscopy | B | — | 10 (best 0.84) |
| 6V4U | Cryo-EM structure of SMCR8-C9ORF72-WDR41 complex | electron microscopy | B | — | — |
| 7EL6 | Structure of SMCR8 bound FEM1B | x-ray diffraction | A, B | — | 4 (best 0.80) |
| 7EL6 | Structure of SMCR8 bound FEM1B | x-ray diffraction | A, B | — | — |
| 7MGE | Structure of C9orf72:SMCR8:WDR41 in complex with ARF1 | electron microscopy | B | GDP | 10 (best 0.84) |
| 7MGE | Structure of C9ORF72:SMCR8:WDR41 in complex with ARF1 | electron microscopy | B | GDP | — |
| 7O2W | Structure of the C9orf72-SMCR8 complex | electron microscopy | B | — | 11 (best 0.73) |
| 7O2W | Structure of the C9ORF72-SMCR8 complex | electron microscopy | B | — | — |
| Q8TEV9 | AlphaFold monomer V2.0 prediction for guanine nucleotide exchange protein SMCR8 (Q8TEV9) | predicted | A | — | 11 (best 0.67) |
Ligands
- GDP · Guanosine-5'-diphosphate · in 2 records
Experiment against prediction
- 7EL6 chain B against the predicted model Q9UK73: TM-score 0.95, RMSD 1.59 Å
- 7EL6 chain B against the predicted model Q9UK73: TM-score 0.95, RMSD 1.59 Å
- 7EL6 chain A against the predicted model Q9UK73: TM-score 0.94, RMSD 1.87 Å
- 7EL6 chain A against the predicted model Q9UK73: TM-score 0.94, RMSD 1.87 Å
- 6LT0 chain B against the predicted model Q8TEV9: TM-score 0.90, RMSD 2.69 Å
- 6LT0 chain B against the predicted model Q8TEV9: TM-score 0.90, RMSD 2.69 Å
- 7MGE chain B against the predicted model Q8TEV9: TM-score 0.86, RMSD 3.44 Å
- 7MGE chain B against the predicted model Q8TEV9: TM-score 0.86, RMSD 3.44 Å
- 7O2W chain B against the predicted model Q8TEV9: TM-score 0.85, RMSD 3.35 Å
- 7O2W chain B against the predicted model Q8TEV9: TM-score 0.85, RMSD 3.35 Å
Elsewhere
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