MolNFT v2 · #188851 · protein
Structure of the C9orf72-SMCR8 complex
7O2W · Ubiquitin-like protein SMT3,Guanine nucleotide exchange…: “Structure of the C9orf72-SMCR8 complex”. Electron microscopy at 0, 18 pockets (best druggability 0.73). MolNFT v2 #188851 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7O2W
- Type
- protein
- Length
- 840 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 0
- Source
- Escherichia coli K-12; Homo sapiens; Saccharomyces cerevisiae S288c
- Molecule
- Ubiquitin-like protein SMT3,Guanine nucleotide exchange C9orf72; Guanine nucleotide…
- UniProt
- Q12306, Q96LT7, Q8TEV9, P0AEX9
- Pockets
- 18 · best druggability 0.73
Structure
electron microscopy · resolution 0 · 2 distinct chains · 47% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin-like protein SMT3,Guanine nucleotide exchange C9orf72 | protein | 418 | 40% helix, 7% strand | Q12306, Q96LT7 |
| B | Guanine nucleotide exchange protein SMCR8,Guanine nucleotide exchange protein SMCR8,Maltose/maltodextrin-binding periplasmic protein | protein | 422 | 53% helix, 2% strand | Q8TEV9, P0AEX9 |
Pockets
18 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 219 | 0.73 | 0.88 | 46 | empty |
| 2 | 916 | 0.73 | 0.77 | 74 | empty |
| 3 | 342 | 0.70 | 0.83 | 40 | empty |
| 4 | 389 | 0.67 | 0.80 | 57 | empty |
| 5 | 181 | 0.66 | 0.85 | 31 | empty |
Interfaces
1 interface between chains.
- A–B · 2357 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 7O2W · Structure of the C9ORF72-SMCR8 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q96LT7 · AlphaFold monomer V2.0 prediction for guanine nucleotide exchange C9ORF72 (Q96LT7) · a predicted model of the same protein · chain A against A, TM-score 0.93
- Q8TEV9 · AlphaFold monomer V2.0 prediction for guanine nucleotide exchange protein SMCR8 (Q8TEV9) · a predicted model of the same protein · chain B against A, TM-score 0.85
- Q12306 · AlphaFold monomer V2.0 prediction for ubiquitin-like protein SMT3 (Q12306) · a predicted model of the same protein · chain A against A, TM-score 0.11
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12306
- Every structure of UniProt Q96LT7
- Every structure of UniProt Q8TEV9
- Every structure of UniProt P0AEX9
- Elsewhere: RCSB PDB 7O2W · PDBe 7O2W · UniProt Q12306 · UniProt Q96LT7 · UniProt Q8TEV9 · UniProt P0AEX9
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