UniProt Q96LT7
Guanine nucleotide exchange C9orf72 (Q96LT7)
Guanine nucleotide exchange C9orf72 (UniProt Q96LT7): 7 experimental structures and 1 predicted model on GenesisL1, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q96LT7
- Protein
- Guanine nucleotide exchange C9orf72
- Experimental structures
- 7
- Predicted models
- 1
- Pockets
- 17 · 2 records with a druggable one
Structures
8 records of Q96LT7 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6LT0 | Cryo-EM structure of C9ORF72-SMCR8-WDR41 | electron microscopy | C, F | — | — |
| 6V4U | Cryo-EM structure of SMCR8-C9orf72-WDR41 complex | electron microscopy | A | — | 10 (best 0.81) |
| 6V4U | Cryo-EM structure of SMCR8-C9ORF72-WDR41 complex | electron microscopy | A | — | — |
| 7MGE | Structure of C9orf72:SMCR8:WDR41 in complex with ARF1 | electron microscopy | C | — | 7 (best 0.84) |
| 7MGE | Structure of C9ORF72:SMCR8:WDR41 in complex with ARF1 | electron microscopy | C | — | — |
| 7O2W | Structure of the C9orf72-SMCR8 complex | electron microscopy | A | — | — |
| 7O2W | Structure of the C9ORF72-SMCR8 complex | electron microscopy | A | — | — |
| Q96LT7 | AlphaFold monomer V2.0 prediction for guanine nucleotide exchange C9ORF72 (Q96LT7) | predicted | A | — | — |
Experiment against prediction
- 6LT0 chain F against the predicted model Q96LT7: TM-score 0.98, RMSD 1.16 Å
- 6LT0 chain C against the predicted model Q96LT7: TM-score 0.98, RMSD 1.16 Å
- 7MGE chain C against the predicted model Q96LT7: TM-score 0.96, RMSD 1.54 Å
- 7MGE chain C against the predicted model Q96LT7: TM-score 0.96, RMSD 1.54 Å
- 7O2W chain A against the predicted model Q96LT7: TM-score 0.93, RMSD 2.40 Å
- 7O2W chain A against the predicted model Q96LT7: TM-score 0.93, RMSD 2.40 Å
- 6V4U chain A against the predicted model Q96LT7: TM-score 0.85, RMSD 2.94 Å
- 6V4U chain A against the predicted model Q96LT7: TM-score 0.85, RMSD 2.94 Å
- 7O2W chain A against the predicted model Q12306: TM-score 0.11, RMSD 5.12 Å
- 7O2W chain A against the predicted model Q12306: TM-score 0.11, RMSD 5.12 Å
Elsewhere
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