Research workbench
Crystal structure of GTPase domain of human septin 2 / septin 11 heterocomplex
Analyse Crystal structure of GTPase domain of human septin 2 / septin 11 heterocomplex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6UPQ
- Type
- protein
- Length
- 517 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Septin-2; Septin-11
- UniProt
- Q15019, Q9NVA2
- Ligands
- GDP, GTP, MG
- Pockets
- 5 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Septin-2 | protein | 270 | 40% helix, 20% strand | Q15019 |
| B | Septin-11 | protein | 247 | 34% helix, 24% strand | Q9NVA2 |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · chains A, B
- GTP · Guanosine-5'-triphosphate · ligand · chains A, B
- MG · Magnesium ion · metal · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 77 | 0.73 | 0.97 | 25 | empty |
| 2 | 373 | 0.72 | 0.84 | 56 | GTP, MG |
| 3 | 438 | 0.72 | 0.82 | 62 | GDP |
| 4 | 50 | 0.42 | 0.83 | 18 | empty |
| 5 | 77 | 0.37 | 0.77 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1984 Ų buried · 28 hydrogen bonds · protein-protein
Compared structures
- 6UPQ · Crystal Structure of GTPase Domain of Human Septin 2 / Septin 11 Heterocomplex · the same entry in another collection · chain A against A, TM-score 1.00
- Q15019 · AlphaFold monomer V2.0 prediction for septin-2 (Q15019) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q9NVA2 · AlphaFold monomer V2.0 prediction for septin-11 (Q9NVA2) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15019
- Every structure of UniProt Q9NVA2
- Elsewhere: RCSB PDB 6UPQ · PDBe 6UPQ · UniProt Q15019 · UniProt Q9NVA2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.