Research workbench
The crystal structure of a TRP channel peptide bound to a G protein beta gamma heterodimer
Analyse The crystal structure of a TRP channel peptide bound to a G protein beta gamma… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6RMV
- Type
- protein
- Length
- 412 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine…
- UniProt
- P62874, P63213, Q5F4S7
- Pockets
- 3 · best druggability 0.80
Structure
x-ray diffraction · 3 distinct chains · 16% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 337 | 7% helix, 47% strand | P62874 |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 62 | 52% helix, 0% strand | P63213 |
| C | Transient receptor potential cation channel, subfamily M, member 3 | protein | 13 | 62% helix, 0% strand | Q5F4S7 |
Ligands and binding sites
- GOL · Glycerol · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 601 | 0.80 | 0.86 | 56 | empty |
| 2 | 161 | 0.43 | 0.74 | 21 | empty |
| 3 | 63 | 0.34 | 0.77 | 19 | GOL |
Interfaces
2 interfaces between chains.
- A–B · 2213 Ų buried · 20 hydrogen bonds · protein-protein
- A–C · 526 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6RMV · The crystal structure of a TRP channel peptide bound to a G protein beta gamma heterodimer · the same entry in another collection · chain A against A, TM-score 1.00
- P62874 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain A against A, TM-score 0.99
- P63213 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain B against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62874
- Every structure of UniProt P63213
- Every structure of UniProt Q5F4S7
- Elsewhere: RCSB PDB 6RMV · PDBe 6RMV · UniProt P62874 · UniProt P63213 · UniProt Q5F4S7
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