Research workbench
Sex hormone-binding globulin mutant E176K in complex with ipi
Analyse Sex hormone-binding globulin mutant E176K in complex with ipi in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6PYA
- Type
- protein
- Length
- 175 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sex hormone-binding globulin
- UniProt
- P04278
- Ligands
- P57, CA
- Pockets
- 2 · best druggability 0.80
Structure
x-ray diffraction · 1 distinct chain · 5% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sex hormone-binding globulin | protein | 175 | 5% helix, 48% strand | P04278 |
Ligands and binding sites
- P57 · 3-[(1H-imidazol-1-yl)methyl]-2-phenyl-1H-indole · ligand · chains A
- CA · Calcium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 228 | 0.80 | 0.93 | 32 | P57 |
| 2 | 53 | 0.29 | 0.75 | 16 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6PYA · Sex Hormone-binding globulin mutant E176K in complex with IPI · the same entry in another collection · chain A against A, TM-score 1.00
- P04278 · AlphaFold monomer V2.0 prediction for sex hormone-binding globulin (P04278) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04278
- Elsewhere: RCSB PDB 6PYA · PDBe 6PYA · UniProt P04278
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