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A complex structure of arrestin-2 bound to neurotensin receptor 1
Analyse A complex structure of arrestin-2 bound to neurotensin receptor 1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6PWC
- Type
- protein
- Length
- 1,055 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neurotensin receptor type 1; Neurotensin peptide; Beta-arrestin-1; FAB30 heavy chain…
- UniProt
- P30989, P49407
- Pockets
- 20 · best druggability 0.79
Structure
electron microscopy · 5 distinct chains · 28% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| R | Neurotensin receptor type 1 | protein | 323 | 77% helix, 3% strand | P30989 |
| B | Neurotensin peptide | protein | 5 | 0% helix, 0% strand | — |
| A | Beta-arrestin-1 | protein | 350 | 6% helix, 45% strand | P49407 |
| H | FAB30 heavy chain | protein | 194 | 5% helix, 55% strand | — |
| L | FAB30 light chain | protein | 183 | 6% helix, 46% strand | — |
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 591 | 0.79 | 0.85 | 92 | empty |
| 2 | 674 | 0.79 | 0.84 | 85 | empty |
| 3 | 644 | 0.77 | 0.83 | 76 | empty |
| 4 | 631 | 0.76 | 0.82 | 92 | empty |
| 5 | 764 | 0.73 | 0.79 | 80 | empty |
Interfaces
6 interfaces between chains.
- H–L · 555 Ų buried · 3 hydrogen bonds · protein-protein
- R–A · 384 Ų buried · 2 hydrogen bonds · protein-protein
- R–B · 237 Ų buried · 0 hydrogen bonds · protein-protein
- A–H · 234 Ų buried · 2 hydrogen bonds · protein-protein
- R–L · 25 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6PWC · A complex structure of arrestin-2 bound to neurotensin receptor 1 · the same entry in another collection · chain B against B, TM-score 1.00
- P30989 · AlphaFold monomer V2.0 prediction for neurotensin receptor type 1 (P30989) · a predicted model of the same protein · chain R against A, TM-score 0.92
- P49407 · AlphaFold monomer V2.0 prediction for beta-arrestin-1 (P49407) · a predicted model of the same protein · chain A against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30989
- Every structure of UniProt P49407
- Elsewhere: RCSB PDB 6PWC · PDBe 6PWC · UniProt P30989 · UniProt P49407
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