UniProt P49407
Beta-arrestin-1 (P49407)
Beta-arrestin-1 (UniProt P49407): 6 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P49407
- Protein
- Beta-arrestin-1
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 7 · 1 record with a druggable one
Structures
7 records of P49407 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2IV8 | beta appendage in complex with b-arrestin peptide | x-ray diffraction | P, Q | — | — |
| 2IV8 | Beta appendage in complex with B-arrestin peptide | x-ray diffraction | P, Q | — | — |
| 6PWC | A complex structure of arrestin-2 bound to neurotensin receptor 1 | electron microscopy | A | — | — |
| 6TKO | Phosphorylated turkey BETA1 adrenoceptor with bound agonist formoterol coupled to arrestin-2 in… | electron microscopy | B | — | — |
| 6UP7 | Neurotensin receptor and ARRESTIN2 complex | electron microscopy | B | PIO | — |
| 8AS3 | Structure of arrestin2 in complex with 6P CCR5 phosphopeptide and Fab30 | x-ray diffraction | A | — | 7 (best 0.71) |
| P49407 | AlphaFold monomer V2.0 prediction for beta-arrestin-1 (P49407) | predicted | A | — | — |
Ligands
- PIO · [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2, 3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate · in 1 record
Experiment against prediction
- 2IV8 chain Q against the predicted model P49407: TM-score 0.97, RMSD 0.09 Å
- 2IV8 chain Q against the predicted model P49407: TM-score 0.97, RMSD 0.09 Å
- 6UP7 chain B against the predicted model P49407: TM-score 0.90, RMSD 2.49 Å
- 6TKO chain B against the predicted model P49407: TM-score 0.88, RMSD 2.76 Å
- 6PWC chain A against the predicted model P49407: TM-score 0.88, RMSD 2.90 Å
- 8AS3 chain A against the predicted model P49407: TM-score 0.87, RMSD 3.12 Å
- 2IV8 chain P against the predicted model P49407: TM-score 0.55, RMSD 0.47 Å
- 2IV8 chain P against the predicted model P49407: TM-score 0.55, RMSD 0.47 Å
Elsewhere
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